Antibody

PKA Substrate (RRXS/T) (100G7)

Clonality: monoclonal
Host: Rabbit
Isotype: IgG
Methods: ELISA, IP, WB
Source: Cell Signaling
Cat# 9624
Reference:
Townsend, 2007
Formulation: liquid, HEPES, saline, BSA, glycerol
Reactivity:
Reacts in: Non-specific

Immunogen/Epitope

immunogen = synthetic phospho-PKA substrate peptides (KLH coupled)

Specificity

detects peptides and proteins containing a phospho serine/threonine residue with arginine at the -3 and -2 positions. It is a useful tool in identifying new substrates of PKA. The antibody recognizes other -3 arginine-bearing phospho-Ser/Thr peptides, such as substrate motifs for Akt and PKC, to a lesser extent. It does not recognize the nonphosphor substrate motif peptides

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References

Paper Citations

  1. . Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. J Biol Chem. 2007 Nov 16;282(46):33305-12. PubMed.

Further Reading

No Available Further Reading