Antibody

nicotinic AChRα7 (mAb 306)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: Sigma Aldrich
Cat# M220
Reference:
Clifford, 2008
Formulation: buffered aqueous solution, purified IgG, phosphate buffer, saline, azide
Reactivity:
Reacts in: Chicken, Human, Rat

Immunogen/Epitope

immunogen = recombinant native and denatured α7 subunit (amino acids 380-400, binds α-bungarotoxin) of the nicotinic acetylcholine receptor from chicken and the denatured α7 subunit from rat

Specificity

binds to denatured chick α7 subunit of AchR and to denatured rat and human α7, but not well to native mammalian α7

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References

Paper Citations

  1. Clifford PM, Siu G, Kosciuk M, Levin EC, Venkataraman V, D'Andrea MR, Nagele RG. Alpha7 nicotinic acetylcholine receptor expression by vascular smooth muscle cells facilitates the deposition of Abeta peptides and promotes cerebrovascular amyloid angiopathy. Brain Res. 2008 Oct 9;1234:158-71. PubMed.

Further Reading

No Available Further Reading