Antibody

Nicastrin

Clonality: polyclonal
Host: Rabbit
Isotype: IgG
Methods: WB
Source: A B R - Thermo Scientific
Cat# PA1-758
reference
Lee, 2002
Gu, 2002
Puglielli, 2001
Deng, 2006
Formulation: epitope affinity purified IgG, PBS, BSA, azide
Reactivity:
Reacts in: Human, Mouse

Immunogen/Epitope

immunogen = synthetic peptide corr. to aa 688-708 of human nicastrin; one aa substitution between human and mouse sequence

Specificity

Nicastrin in tissues and cells; ~110 kDa in WB

Comments / Questions

No Available Comments

Make a comment or submit a question

To make a comment you must login or register.

References

Paper Citations

  1. . Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch. J Biol Chem. 2002 Nov 22;277(47):45013-9. PubMed.
  2. . APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes. J Biol Chem. 2003 Feb 28;278(9):7374-80. PubMed.
  3. . Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat Cell Biol. 2001 Oct;3(10):905-12. PubMed.
  4. . Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology. J Neurosci. 2006 Apr 5;26(14):3845-54. PubMed.

Further Reading

No Available Further Reading