Antibody

NeuN (A60)

Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Methods: IC, IF, IH, IP, WB
Source: Chemicon and Upstate are Millipore
Cat# MAB377
References:
Veeraraghavalu, 2010
Heneka, 2010
He, 2009
Mallucci, 2007
Pereira, 2007
(unspecified formulation for
Burré J, 2010
Kapoor, 2010
Jäderstad, 2010
Wang, J, 2010
Demars, 2010
Loane, 2009
Varvel, 2009
Rose, 2009 )
Formulation: liquid, purified Ig, phosphate buffer, NaCl, azide<br />Also available prediluted, <a href="http://www.millipore.com/catalogue/item/ihcr1001-6">IHR1001-6</a>
Reactivity:
Reacts in: Avian (various), Primate (various), Chicken, Salamander, Ferret, Pig, Human, Mouse, Rat
others not tested

Immunogen/Epitope

immunogen =
purified cell nuclei from mouse brain

Specificity

reacts with most neuronal cell types; is an excellent marker for neurons in primary cultures and in retinoic acid-stimulated P19 cells

Comments / Questions

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References

Paper Citations

  1. . Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling. J Neurosci. 2010 May 19;30(20):6903-15. PubMed.
  2. . Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine. Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):6058-63. PubMed.
  3. . Interruption of beta-catenin signaling reduces neurogenesis in Alzheimer's disease. J Neurosci. 2009 May 20;29(20):6545-57. PubMed.
  4. . Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice. Neuron. 2007 Feb 1;53(3):325-35. PubMed.
  5. . An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5638-43. PubMed.
  6. . Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science. 2010 Sep 24;329(5999):1663-7. PubMed.
  7. . Loss of thyroid hormone receptor β is associated with increased progenitor proliferation and NeuroD positive cell number in the adult hippocampus. Neurosci Lett. 2011 Jan 7;487(2):199-203. PubMed.
  8. . Communication via gap junctions underlies early functional and beneficial interactions between grafted neural stem cells and the host. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5184-9. PubMed.
  9. . Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6498-503. Epub 2010 Mar 15 PubMed.
  10. . Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice. J Neurosci Res. 2010 Aug 1;88(10):2103-17. PubMed.
  11. . Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury. Nat Med. 2009 Apr;15(4):377-9. PubMed.
  12. . NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease. J Clin Invest. 2009 Dec;119(12):3692-702. PubMed.
  13. . Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. J Neurosci. 2009 Jan 28;29(4):1115-25. PubMed.

External Citations

  1. IHR1001-6

Further Reading

No Available Further Reading