Antibody

Iba-1

Clonality: polyclonal
Host: Rabbit
Methods: IC
Source: Wako Chemicals
Cat# 019-19741
References:
Bhaskar K, 2010
Lewis TL, 2010
Lee, S, 2010
Grathwohl, 2009
Yan, 2009
Ding, 2008
Choi, 2008
Maier, 2008
Ajami, 2008
Formulation: sera, affinity purified, TBS, no preservatives or stabilizers
Reactivity:
Reacts in: Human, Mouse, Rat

Immunogen/Epitope

Immunogen = synthetic peptide corresponding to the C-terminus of Iba-1 (Ionized calcium binding adaptor molecule 1)

Specificity

Microglia and macrophages, but no cross reactivity with neurons or astrocytes

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References

Paper Citations

  1. . Regulation of tau pathology by the microglial fractalkine receptor. Neuron. 2010 Oct 6;68(1):19-31. PubMed.
  2. . Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer disease. J Biol Chem. 2010 Nov 19;285(47):36958-68. Epub 2010 Sep 16 PubMed.
  3. . CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. Am J Pathol. 2010 Nov;177(5):2549-62. PubMed.
  4. . Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nat Neurosci. 2009 Nov;12(11):1361-3. PubMed.
  5. . Characterizing the appearance and growth of amyloid plaques in APP/PS1 mice. J Neurosci. 2009 Aug 26;29(34):10706-14. PubMed.
  6. . Retinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model. J Neurosci. 2008 Nov 5;28(45):11622-34. PubMed.
  7. . Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation. Neuron. 2008 Aug 28;59(4):568-80. PubMed.
  8. . Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice. J Neurosci. 2008 Jun 18;28(25):6333-41. PubMed.
  9. . Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci. 2007 Dec;10(12):1538-43. PubMed.

Further Reading

No Available Further Reading