Antibody

Huntingtin (1HU-4C8)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: Chemicon and Upstate are Millipore
Cat# MAB2166
reference,
Graham, 2006
Peters, 2002
Formulation: liquid, ascites, no preserves
Reactivity:
Reacts in: Rabbit, Human, Monkey, Hamster, Mouse, Rat
others not tested

Immunogen/Epitope

immunogen = Huntingtin fragment from aa 181-810 as a fusion protein

Specificity

Huntingtin Protein. No detectable cross reactivity to other proteins by WB

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References

Paper Citations

  1. Graham RK, Deng Y, Slow EJ, Haigh B, Bissada N, Lu G, Pearson J, Shehadeh J, Bertram L, Murphy Z, Warby SC, Doty CN, Roy S, Wellington CL, Leavitt BR, Raymond LA, Nicholson DW, Hayden MR. Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin. Cell. 2006 Jun 16;125(6):1179-91. PubMed.
  2. Peters PJ, Ning K, Palacios F, Boshans RL, Kazantsev A, Thompson LM, Woodman B, Bates GP, D'Souza-Schorey C. Arfaptin 2 regulates the aggregation of mutant huntingtin protein. Nat Cell Biol. 2002 Mar;4(3):240-5. PubMed.

Further Reading

No Available Further Reading