Antibody

GSK-3β pSer9

Clonality: polyclonal
Host: Rabbit
Methods: IC, IH, WB
Source: Cell Signaling
Cat# 9336
References:
Rao, 2008
Peineau, 2007
Rockenstein, 2007
Papasozo- menos, 2002
Tanemura, 2006
Formulation: protein A, affinity purified, HEPES, BSA, glycerol
Reactivity:
Reacts in: Human, Monkey, Mouse, Rat
expect Zebrafish from homology

Immunogen/Epitope

immunogen = syntheticphospho-peptide (KLH coupled) derived from the sequence of human GSK-3β

Specificity

recognizes endogenous levels of GSK-3 only when phosphorylated at Ser9 of GSK-3β may cross weakly with the phosphorylated form of GSK-3α due to high sequence homology

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References

Paper Citations

  1. . Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression. J Neurosci. 2008 Nov 19;28(47):12241-54. PubMed.
  2. . LTP inhibits LTD in the hippocampus via regulation of GSK3beta. Neuron. 2007 Mar 1;53(5):703-17. PubMed.
  3. . Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation. J Neurosci. 2007 Feb 21;27(8):1981-91. PubMed.
  4. . Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3 beta but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly abolishes hyperphosphorylation of tau: implications for Alzheimer's disease. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1140-5. PubMed.
  5. . Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1). J Biol Chem. 2006 Feb 24;281(8):5037-41. PubMed.

Further Reading

No Available Further Reading