Antibody

F4/80 (CI:A3-1)

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Clonality: monoclonal
Host: Rat
Isotype: IgG2b
Source: AbD Serotec
Cat# MCA497GA
References:
Grathwohl, 2009
Anderson, 2008
Maier, 2008
(all, unspecified formulation)
Mildner, 2008
Formulation: liquid, supernatant, affinity purified, PBS, azide.<br />Also <a href="http://www.ab-direct.com/catalog/productlist.aspx?SearchType=Simple&amp;SearchString=f4%2f80" target="_new">available</a> as low endotoxin
Reactivity:
Reacts in: Mouse

Immunogen/Epitope

immunogen = thioglycollate stimulated peritoneal macrophages from C57/BL mice

Specificity

detects 160 kDa F4/80 in macrophages

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References

Paper Citations

  1. Grathwohl SA, Kälin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL, Jucker M. Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nat Neurosci. 2009 Nov;12(11):1361-3. PubMed.
  2. Anderson JM, Hampton DW, Patani R, Pryce G, Crowther RA, Reynolds R, Franklin RJ, Giovannoni G, Compston DA, Baker D, Spillantini MG, Chandran S. Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis. Brain. 2008 Jul;131(Pt 7):1736-48. PubMed.
  3. Maier M, Peng Y, Jiang L, Seabrook TJ, Carroll MC, Lemere CA. Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice. J Neurosci. 2008 Jun 18;28(25):6333-41. PubMed.
  4. Mildner A, Schmidt H, Nitsche M, Merkler D, Hanisch UK, Mack M, Heikenwalder M, Brück W, Priller J, Prinz M. Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions. Nat Neurosci. 2007 Dec;10(12):1544-53. PubMed.

External Citations

  1. available

Further Reading

No Available Further Reading