Antibody

eIF2α phos (119A11)

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Clonality: monoclonal
Host: Rabbit
Isotype: iGg
Source: Cell Signaling
Cat# 3597
O'Connor, 2008
Formulation: liquid, affinity purified, sodium HEPES, BSA, glycerol
Reactivity:
Reacts in: Human, Monkey, Mouse, Rat, Drosophila

Immunogen/Epitope

immunogen = synthetic peptide (KLH-coupled) derived from the carboxy terminal sequence of eIF2α.

Specificity

detects endogenous eIF2alpha only when phosphorylated at Ser51; does not recognize eIF2alpha phosphorylated at other sites

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References

Paper Citations

  1. O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, Hébert SS, De Strooper B, Haass C, Bennett DA, Vassar R. Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron. 2008 Dec 26;60(6):988-1009. PubMed.

Further Reading

No Available Further Reading