Antibody

BACE (61-3E7)

Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Methods: IC, IH, IP, WB
Source: Chemicon and Upstate are Millipore
Cat# MAB5308
references:
Li, 2003
Fukumoto, 2002
Lee, 2002
Formulation: purified, PBS, azide
Reactivity:
Reacts in: Primate (various), Human, Mouse, Rat
other species not tested

Immunogen/Epitope

immunogen = synthetic peptide, C-terminus of BACE

Specificity

BACE, not BACE2; recognizes pro and mature forms

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References

Paper Citations

  1. . Positive and negative regulation of APP amyloidogenesis by sumoylation. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):259-64. PubMed.
  2. . Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease. Arch Neurol. 2002 Sep;59(9):1381-9. PubMed.
  3. . Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch. J Biol Chem. 2002 Nov 22;277(47):45013-9. PubMed.

Further Reading