Antibody

BACE (61-3E7)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: Chemicon and Upstate are Millipore
Cat# MAB5308
references:
Li, 2003
Fukumoto, 2002
Lee, 2002
Formulation: purified, PBS, azide
Reactivity:
Reacts in: Primate (various), Human, Mouse, Rat
other species not tested

Immunogen/Epitope

immunogen = synthetic peptide, C-terminus of BACE

Specificity

BACE, not BACE2; recognizes pro and mature forms

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References

Paper Citations

  1. Li Y, Wang H, Wang S, Quon D, Liu YW, Cordell B. Positive and negative regulation of APP amyloidogenesis by sumoylation. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):259-64. PubMed.
  2. Fukumoto H, Cheung BS, Hyman BT, Irizarry MC. Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease. Arch Neurol. 2002 Sep;59(9):1381-9. PubMed.
  3. Lee SF, Shah S, Li H, Yu C, Han W, Yu G. Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch. J Biol Chem. 2002 Nov 22;277(47):45013-9. PubMed.

Further Reading