Antibody

Aβ soluble Oligomers

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Clonality: polyclonal
Host: Rabbit
Isotype: Ig
Source: Biosource Invitrogen
Cat# AHB0052;
"A11";
Paper, Kayed et al., 2003
References:
Chung, E, 2010
Jimenez, 2008
Adlard, 2008
Petrushina, 2007
Maezawa, 2008
Wang, 2007
Formulation: liquid, affinity purified, PBS, azide
Reactivity:
Reacts in: Human
expect rat, mouse and many others

Immunogen/Epitope

immunogen = synthetic molecular mimic of soluble oligomers

Specificity

A11 recognizes amino acid sequence independent oligomers of proteins and peptides, including Aβ40 and Aβ42; not monomers or mature fibers of proteins or peptides

Note

not qualified for WB

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References

Paper Citations

  1. . Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science. 2003 Apr 18;300(5618):486-9. PubMed.
  2. . Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse. BMC Neurosci. 2010;11:130. PubMed.
  3. . Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic. J Neurosci. 2008 Nov 5;28(45):11650-61. PubMed.
  4. . Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. Neuron. 2008 Jul 10;59(1):43-55. PubMed.
  5. . Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice. J Neurosci. 2007 Nov 14;27(46):12721-31. PubMed.
  6. . Congo red and thioflavin-T analogs detect Abeta oligomers. J Neurochem. 2008 Jan;104(2):457-68. PubMed.
  7. . Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease. J Clin Invest. 2007 Nov;117(11):3393-402. PubMed.

Further Reading

No Available Further Reading