Antibody

Aβ 40 (G2-10)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG2b,κ
Source: Genetics Company, Inc.
Cat# AB-10
References:
Rajendran, 2006
Runtz, 2002
Lichtenthaler, 2002
(all, unspecified formulation)
Formulation: affinity purified IgG, PBS, azide
Reactivity:
Reacts in: Dog, Human, Guinea Pig, Mouse, Rat, Cynomolgus

Immunogen/Epitope

C-terminal epitope mapping corr. to amino acid residue 31-40 of human Aβ peptide

Specificity

recognizes Aβ-peptide, aa 31-40; selective for C-terminal of Aβ- 1-40; not Aβ 1-38, Aβ 1-39, Aβ 1-42, Aβ 1-43 or Aβ 1-44

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References

Paper Citations

  1. Rajendran L, Honsho M, Zahn TR, Keller P, Geiger KD, Verkade P, Simons K. Alzheimer's disease beta-amyloid peptides are released in association with exosomes. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11172-7. PubMed.
  2. Runz H, Rietdorf J, Tomic I, de Bernard M, Beyreuther K, Pepperkok R, Hartmann T. Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells. J Neurosci. 2002 Mar 1;22(5):1679-89. PubMed.
  3. Lichtenthaler SF, Beher D, Grimm HS, Wang R, Shearman MS, Masters CL, Beyreuther K. The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1365-70. PubMed.

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