Antibody

Aβ (10D5)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: amyloidβ 10D5
(F Bard,
Elan Pharmaceuticals, South San Francisco, CA
paper:
Bard, et al.,
PNAS Feb 3, 2003)
Reference:
Price, 2009
Roberson, 2007
Formulation: purified
Reactivity:
Reacts in: Human, Mouse

Immunogen/Epitope

immunogen = synthetic Aβ1–28 coupled to a carrier protein (epitope at aa. 3-7)

Specificity

binds amyloid plaques and triggers phagocytosis

Comments / Questions

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References

Paper Citations

  1. Price JL, McKeel DW, Buckles VD, Roe CM, Xiong C, Grundman M, Hansen LA, Petersen RC, Parisi JE, Dickson DW, Smith CD, Davis DG, Schmitt FA, Markesbery WR, Kaye J, Kurlan R, Hulette C, Kurland BF, Higdon R, Kukull W, Morris JC. Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease. Neurobiol Aging. 2009 Jul;30(7):1026-36. PubMed.
  2. Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L. Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science. 2007 May 4;316(5825):750-4. PubMed.

External Citations

  1. Bard, et al.

Further Reading

No Available Further Reading