Clonality: monoclonal
Host: Mouse
Source: JRF/Aβtot/17
(Paul Mathews, New York University, School of Medicine,
Marc Merken,
Johnson & Johnson Pharm. R&D,
paper)
References:
Gandy, 2010
Trinchese, 2008
Mi, 2007
Reactivity:
Reacts in: Human

Immunogen/Epitope

immunogen = human Aβ_1-40

Specificity

amyloid-beta, binds within residues 1-15

Comments / Questions

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References

Paper Citations

1. Gandy S, Simon AJ, Steele JW, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Checler F, Glabe C, Bilker WB, Abel T, Schmeidler J, Ehrlich ME. Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers. Ann Neurol. 2010 Aug;68(2):220-30. PubMed.
2. Trinchese F, Fa' M, Liu S, Zhang H, Hidalgo A, Schmidt SD, Yamaguchi H, Yoshii N, Mathews PM, Nixon RA, Arancio O. Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. J Clin Invest. 2008 Aug;118(8):2796-807. PubMed.
3. Mi W, Pawlik M, Sastre M, Jung SS, Radvinsky DS, Klein AM, Sommer J, Schmidt SD, Nixon RA, Mathews PM, Levy E. Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. Nat Genet. 2007 Dec;39(12):1440-2. PubMed.

Other Citations

1. Marc Merken

External Citations

1. Paul Mathews
2. paper

Further Reading

No Available Further Reading