Antibody

Aβ 1-16

Clonality: monoclonal
Host: Mouse
Methods: ELISA, IB
Source: IC16
(Claus U. Pietrzik, Institute of Physiological Chemistry and Pathobiochemistry, Molecular Neurodegeneration, Johannes-Gutenberg-University Mainz, Mainz, Germany)
paper)
Reference:
Richter L, 2010
Reactivity:
Reacts in: Human

Immunogen/Epitope

immunogen = synthetic human Ab peptide 1–16, cross-linked to keyhole limpet hemocyanin

Specificity

recognizes residues 1-16 of Amyloid β. Hybridoma cells were generated by standard procedures and screened for recognition of HSA cross-linked to Ab 1-16 by ELISA; recognition of synthetic Ab 1–42 on a standardized dot blot procedure was confirmed and the epitope mapped to Ab 1–8 using a peptide array spanning the entire sequence of Ab

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References

Paper Citations

  1. . Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14597-602. PubMed.

External Citations

  1. Claus U. Pietrzik
  2. paper

Further Reading

No Available Further Reading