Antibody

APP or β-Amyloid (6E10)

Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Methods: ELISA, IB, IC, IF, IH, IP, WB
Source: BioLegend
Cat# 803004 (25 µl), RRID AB_2715854
Cat# 803001 (200 µl), RRID AB_2564653
Cat# 803002 (500 µl), RRID AB_2564654
Cat# 803003 (1 ml), RRID AB_2564652
Previously Covance Catalog# SIG-39320
Formulation: Purified by affinity chromatography. PBS, no preservatives or carrier proteins.
Reactivity:
Reacts in: Human, Mouse
Availability: Available from BioLegend

Immunogen/Epitope

epitope lies within amino acids 3-8 of beta amyloid (EFRHDS)

Specificity

reactive to aa 1-16 Aβ and to APP; reacts to the abnormally processed isoforms, as well as precursor forms

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References

No Available References

Further Reading

Papers

  1. . Lack of correlation between plaque burden and cognition in the aged monkey. Acta Neuropathol. 1997 Nov;94(5):471-8. PubMed.
  2. . Pitfalls in the quantitative estimation of beta-amyloid immunoreactivity in human brain tissue. Histochem Cell Biol. 1998 Oct;110(4):439-45. PubMed.
  3. . Diffuse, lake-like amyloid-beta deposits in the parvopyramidal layer of the presubiculum in Alzheimer disease. J Neuropathol Exp Neurol. 1998 Jul;57(7):674-83. PubMed.