Antibody

APP or β-Amyloid (4G8)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG2b
Source: BioLegend
Cat# 800708 (50 µl) RRID AB_2734547
Cat# 800709 (200 µl) RRID AB_2565325
Cat# 800710 (500 µl) RRID AB_2565326
Cat# 800711 (1 ml) RRID AB_2565324
Previously Covance Cat# SIG-39200
Formulation: crude ascites
Reactivity:
Reacts in: Human, Mouse
Availability: Available from BioLegend

Immunogen/Epitope

epitope within amino acids 18-23 of the Aβ peptide

Specificity

reactive to amino acids 17-24 of Aβ and to APP

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References

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Further Reading

Papers

  1. Gandy S, Simon AJ, Steele JW, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Checler F, Glabe C, Bilker WB, Abel T, Schmeidler J, Ehrlich ME. Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers. Ann Neurol. 2010 Aug;68(2):220-30. PubMed.
  2. Mi W, Pawlik M, Sastre M, Jung SS, Radvinsky DS, Klein AM, Sommer J, Schmidt SD, Nixon RA, Mathews PM, Levy E. Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. Nat Genet. 2007 Dec;39(12):1440-2. PubMed.
  3. Wang J, Ho L, Chen L, Zhao Z, Zhao W, Qian X, Humala N, Seror I, Bartholomew S, Rosendorff C, Pasinetti GM. Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease. J Clin Invest. 2007 Nov;117(11):3393-402. PubMed.
  4. Tampellini D, Magrané J, Takahashi RH, Li F, Lin MT, Almeida CG, Gouras GK. Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations. J Biol Chem. 2007 Jun 29;282(26):18895-906. PubMed.
  5. Ostrowski SM, Wilkinson BL, Golde TE, Landreth G. Statins reduce amyloid-beta production through inhibition of protein isoprenylation. J Biol Chem. 2007 Sep 14;282(37):26832-44. PubMed.