Antibody

APP, full length

Clonality: polyclonal
Host: Rabbit
Methods: DB, IC, IH, WB
Source: anti-APP C8
(Dr. Dennis Selkoe,
Harvard Univ. Medical School, Boston, MA)
References:
Davis, 2010
Senechal, 2008
Wang, 2007
Reactivity:
Reacts in: Mammal (various), Human

Immunogen/Epitope

residues 676-695, comprising the 20 C-terminal amino acids of human ╬▓APP cytoplasmic domain.
Paper, Selkoe et al.

Specificity

recognizes full length APP and all CTFs

Comments / Questions

No Available Comments

Make a comment or submit a question

To make a comment you must login or register.

References

Paper Citations

  1. . Deletion of M1 muscarinic acetylcholine receptors increases amyloid pathology in vitro and in vivo. J Neurosci. 2010 Mar 24;30(12):4190-6. PubMed.
  2. . Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning. Behav Brain Res. 2008 Jan 10;186(1):126-32. PubMed.
  3. . Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease. J Clin Invest. 2007 Nov;117(11):3393-402. PubMed.

Other Citations

  1. Dr. Dennis Selkoe

External Citations

  1. Paper

Further Reading

No Available Further Reading