Antibody

APP (DE2B4)

Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Methods: IC, IH, IP, WB
Source: Abcam
Cat# AB12266
Reference:
Pavlov PF, 2010
Formulation: liquid, supernatant, azide
Reactivity:
Reacts in: Cow, Pig, Human, Monkey
<em>not</em> mouse or rat; others not tested

Immunogen/Epitope

immunogen = synthetic peptide corresp. to aa 1-17 of the mature human Amyloid Precursor Protein, conjugated to KLH.

Specificity

reacts with β-amyloid peptide and secreted APP (alpha-secretase cleaved); has very weak recognition of full length APP and we do not recommend it for this purpose; does however strongly recognize alpha-secretase cleaved soluble APP as well as b-amyloid peptide (40 and 42)

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References

Paper Citations

  1. . Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein. FASEB J. 2011 Jan;25(1):78-88. PubMed.

Further Reading

No Available Further Reading