Antibody

APP, CTFs (C1/6.1)

Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Methods: IP, WB
Source: C1/6.1
(Paul Mathews, New York University, School of Medicine,
Center for Dementia Research)
Research paper
References:
Pavlov PF, 2010
Jiang Y., 2010
Loane, 2009
Hoe, 2009
Formulation: ascites
Reactivity:
Reacts in: Human, Mouse

Immunogen/Epitope

immunogen = synthetic peptide, first 20 amino acids of the C-terminal, cytoplasmic domain of APP (residues 676–695 of APP695)

Specificity

recognizes full length APP and APP CTFs

Comments / Questions

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References

Paper Citations

  1. . Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein. FASEB J. 2011 Jan;25(1):78-88. PubMed.
  2. . Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1630-5. Epub 2009 Dec 28 PubMed.
  3. . Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury. Nat Med. 2009 Apr;15(4):377-9. PubMed.
  4. . Interaction of reelin with amyloid precursor protein promotes neurite outgrowth. J Neurosci. 2009 Jun 10;29(23):7459-73. PubMed.

External Citations

  1. Paul Mathews
  2. Center for Dementia Research
  3. Research paper

Further Reading

No Available Further Reading