Antibody
APP, CTFs (C1/6.1)
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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: C1/6.1
(Paul Mathews,
New York University, School of Medicine,
Center for Dementia Research)
Research paper
References:
Pavlov PF, 2010
Jiang Y., 2010
Loane, 2009
Hoe, 2009
Formulation: ascites
Reactivity:
Reacts in: Human, Mouse
Immunogen/Epitope
immunogen = synthetic peptide, first 20 amino acids of the C-terminal, cytoplasmic domain of APP (residues 676–695 of APP695)
Specificity
recognizes full length APP and APP CTFs
References
Paper Citations
- Pavlov PF, Wiehager B, Sakai J, Frykman S, Behbahani H, Winblad B, Ankarcrona M. Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein. FASEB J. 2011 Jan;25(1):78-88. PubMed.
- Jiang Y, Mullaney KA, Peterhoff CM, Che S, Schmidt SD, Boyer-Boiteau A, Ginsberg SD, Cataldo AM, Mathews PM, Nixon RA. Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1630-5. Epub 2009 Dec 28 PubMed.
- Loane DJ, Pocivavsek A, Moussa CE, Thompson R, Matsuoka Y, Faden AI, Rebeck GW, Burns MP. Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury. Nat Med. 2009 Apr;15(4):377-9. PubMed.
- Hoe HS, Lee KJ, Carney RS, Lee J, Markova A, Lee JY, Howell BW, Hyman BT, Pak DT, Bu G, Rebeck GW. Interaction of reelin with amyloid precursor protein promotes neurite outgrowth. J Neurosci. 2009 Jun 10;29(23):7459-73. PubMed.
External Citations
Further Reading
No Available Further Reading
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