Antibody

APP A4 (22C11)

Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Methods: IF, IH, WB
Source: Chemicon and Upstate are Millipore
Cat# MAB348-100ul
References:
Serneels, 2009
O'Connor, 2008
(unspecified formulation for:
Zhang Y, 2010
Vieira SI, 2010
Nikolev, 2009
Allard, 2008
Maier, 2008
Mi, 2007,
Ostrowski, 2007 )
Formulation: liquid, PBS, azide, purified
Reactivity:
Reacts in: Fish (various), Dog, Pig, Human, Monkey, Mouse, Rat
other species not tested

Immunogen/Epitope

immunogen = purified rhN-terminal epitope (aa 66-81) on the pre-A4 molecule, fusion protein

Specificity

human pre-A4 APP; recognizes all three isoforms of APP, immature ~110kDa, sAPP ~120kDa, and mature ~130kDa; cross reacts with APLP2

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References

Paper Citations

  1. . gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease. Science. 2009 May 1;324(5927):639-42. Epub 2009 Mar 19 PubMed.
  2. . Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron. 2008 Dec 26;60(6):988-1009. PubMed.
  3. . Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19014-9. PubMed.
  4. . Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated. Mol Neurodegener. 2010;5:40. PubMed.
  5. . APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature. 2009 Feb 19;457(7232):981-9. PubMed.
  6. . Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. Neuron. 2008 Jul 10;59(1):43-55. PubMed.
  7. . Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice. J Neurosci. 2008 Jun 18;28(25):6333-41. PubMed.
  8. . Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. Nat Genet. 2007 Dec;39(12):1440-2. PubMed.
  9. . Statins reduce amyloid-beta production through inhibition of protein isoprenylation. J Biol Chem. 2007 Sep 14;282(37):26832-44. PubMed.

Further Reading

No Available Further Reading