Antibody

APP (2.F2.19B4)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: Chemicon and Upstate are Millipore
Cat# MAB343
References:
Zhang Y, 2010
Ostrowski, 2007
Formulation: lyophilized, ascites
Reactivity:
Reacts in: Human, Rat

Immunogen/Epitope

immunogen = C-terminal fragment APP643-695/Jonas

Specificity

full-length APP and selectively with the cytoplasmic C-terminal fragment of APP 643-695

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References

Paper Citations

  1. Zhang Y, Kurup P, Xu J, Carty N, Fernandez SM, Nygaard HB, Pittenger C, Greengard P, Strittmatter SM, Nairn AC, Lombroso PJ. Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19014-9. PubMed.
  2. Ostrowski SM, Wilkinson BL, Golde TE, Landreth G. Statins reduce amyloid-beta production through inhibition of protein isoprenylation. J Biol Chem. 2007 Sep 14;282(37):26832-44. PubMed.

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