Antibody

Aph-1a

Clonality: polyclonal
Host: Rabbit
Methods: IP, WB
Source: Zymed/ Invitrogen
Cat# 38-3600
References:
Tian Y, 2010
Deng, 2006
Formulation: liquid, PBS, azide, affinity purified
Reactivity:
Reacts in: Human, Mouse

Immunogen/Epitope

immunogen = synthetic peptide derived from the C-terminal region of human Aph-1a

Specificity

Aph-1a (~23kDa) long isoform only

Comments / Questions

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References

Paper Citations

  1. . An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production. Nat Struct Mol Biol. 2010 Feb;17(2):151-8. PubMed.
  2. . Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology. J Neurosci. 2006 Apr 5;26(14):3845-54. PubMed.

Further Reading

No Available Further Reading