Antibody

Anti-PBR antibody (EPR5384)

Clonality: monoclonal
Host: Rabbit
Isotype: IgG
Methods: FC, IC, IH, IP, WB
Source: Abcam
Catalog #: ab109497
Formulation: Tissue culture supernatant. PBS 49 percent, sodium azide 0.01 percent, glycerol 50 percent, BSA 0.05 percent.
Reactivity:
Reacts in: Human, Mouse
Availability: Confirmed available December 2014.

Immunogen/Epitope

A synthetic peptide corresponding to residues at the C-terminus of human peripheral benzodiazepine receptor (PBR)/translocator protein (TSPO).

Specificity

This antibody recognizes PBR, also known as TSPO, a mitochondrial transporter that is upregulated in activated microglia.

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References

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Further Reading

Papers

  1. . Regulation of S100B in white adipose tissue by obesity in mice. Adipocyte. 2014 Jul 1;3(3):215-20. Epub 2014 Apr 4 PubMed.
  2. . IF1 limits the apoptotic-signalling cascade by preventing mitochondrial remodelling. Cell Death Differ. 2013 May;20(5):686-97. Epub 2013 Jan 25 PubMed.
  3. . Developmental expression of translocator protein/peripheral benzodiazepine receptor in reproductive tissues. PLoS One. 2013;8(9):e74509. Epub 2013 Sep 5 PubMed.
  4. . Translocator protein 18 kDa (TSPO) is regulated in white and brown adipose tissue by obesity. PLoS One. 2013;8(11):e79980. Epub 2013 Nov 18 PubMed.
  5. . Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis. J Neuroinflammation. 2014 Jan 8;11:3. PubMed.
  6. . Macroglia-microglia interactions via TSPO signaling regulates microglial activation in the mouse retina. J Neurosci. 2014 Mar 5;34(10):3793-806. PubMed.