Antibody
Amyloid-β protofibrils
Quick Links
Clonality: monoclonal
Host: Unknown Host
Isotype: IgG1
Source: mAb1C3
(Hillevi Englund, Department of Public Health/Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden)
References:
Lord, 2009
Englund, 2007
Formulation: supernatant, protein-G purified
Reactivity:
Reacts in: Human
Immunogen/Epitope
immunogen = 30 μg Aβ1–42 Arc protofibrils
Specificity
affinity for Aβ protofibrils, Aβ Arc protofibrils, LMW-Aβ, and Aβ1–16; mAb1C3 did not show any conformation selectivity
References
Paper Citations
- Lord A, Gumucio A, Englund H, Sehlin D, Sundquist VS, Söderberg L, Möller C, Gellerfors P, Lannfelt L, Pettersson FE, Nilsson LN. An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease. Neurobiol Dis. 2009 Dec;36(3):425-34. PubMed.
- Englund H, Sehlin D, Johansson AS, Nilsson LN, Gellerfors P, Paulie S, Lannfelt L, Pettersson FE. Sensitive ELISA detection of amyloid-beta protofibrils in biological samples. J Neurochem. 2007 Oct;103(1):334-45. PubMed.
Further Reading
No Available Further Reading
Comments / Questions
No Available Comments
Make a comment or submit a question
To make a comment you must login or register.