Antibody

Amyloid-β protofibrils

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Clonality: monoclonal
Host: Unknown Host
Isotype: IgG1
Source: mAb1C3
(Hillevi Englund, Department of Public Health/Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden)
References:
Lord, 2009
Englund, 2007
Formulation: supernatant, protein-G purified
Reactivity:
Reacts in: Human

Immunogen/Epitope

immunogen = 30 μg Aβ1–42 Arc protofibrils

Specificity

affinity for Aβ protofibrils, Aβ Arc protofibrils, LMW-Aβ, and Aβ1–16; mAb1C3 did not show any conformation selectivity

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References

Paper Citations

  1. . An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease. Neurobiol Dis. 2009 Dec;36(3):425-34. PubMed.
  2. . Sensitive ELISA detection of amyloid-beta protofibrils in biological samples. J Neurochem. 2007 Oct;103(1):334-45. PubMed.

Further Reading

No Available Further Reading