Antibody

Akt phos Ser473

Clonality: polyclonal
Host: Rabbit
Methods: FC, IC, IF, IP, WB
Source: Cell Signaling
Cat# 9271
References:
Takeda, S, 2010
Townsend, 2007
Dorsey, 2006
Formulation: liquid, HEPES, NaCl, BSA, glycerol, Protein A and affinity purified
Reactivity:
Reacts in: Bovine, Dog, Pig, Human, Hamster, Mouse, Rat, Drosophila
expect monkey, chicken, horse, Xenopus

Immunogen/Epitope

Immunogen = synthetic phospho-peptide corresp. to residues around Ser473 of mouse Akt

Specificity

reacts with Akt when phosphorylated at Ser473; also reacts with Akt2 and Akt3 when phosphorylated at corresponding residues. Does not recognize Akt phosphorylated at other sites, nor does it recognize phosphorylated forms of related kinases such as PKC or p70 S6 kinase

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References

Paper Citations

  1. Takeda S, Sato N, Uchio-Yamada K, Sawada K, Kunieda T, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Morishita R. Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes. Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):7036-41. PubMed.
  2. Townsend M, Mehta T, Selkoe DJ. Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. J Biol Chem. 2007 Nov 16;282(46):33305-12. PubMed.
  3. Dorsey SG, Renn CL, Carim-Todd L, Barrick CA, Bambrick L, Krueger BK, Ward CW, Tessarollo L. In vivo restoration of physiological levels of truncated TrkB.T1 receptor rescues neuronal cell death in a trisomic mouse model. Neuron. 2006 Jul 6;51(1):21-8. PubMed.

Further Reading

No Available Further Reading