Posterior Cortical Atrophy vs Alzheimer's Disease: Aβ42 (CSF)
Meta-analysis showed similar levels of Aβ42 in the cerebrospinal fluid of people with posterior cortical atrophy and people with Alzheimer's disease. However, a paucity of data limited the meta-analysis, with only two eligible studies and a small number of subjects. For comparison, the level of Aβ42 in the CSF of control subjects is nearly double that of people with Alzheimer's disease. The decrease in Aβ42 in the CSF of AD patients is thought to reflect the deposition of the peptide into amyloid plaques in the brain; notably, PCA is frequently associated with Alzheimer’s pathology (Tang-Wai et al., 2004).