Parkinson's Disease Dementia vs Alzheimer's Disease: NFL (CSF)
Meta-analysis did not show a difference in the levels of neurofilament light chain in the cerebrospinal fluid of people with Parkinson's disease dementia and people with Alzheimer's disease. However, a paucity of data limited the meta-analysis, with only two eligible studies. A meta-analysis comparing PDD patients to control subjects found approximately 1.4-fold elevated levels of NFL in the CSF of patients (Bridel et al., 2019). For comparison, CSF NFL levels in AD patients are about double those of controls.