MCI-AD vs MCI-Stable: VLP-1 (CSF)


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Visinin-like protein 1 (VLP-1, also known as VILIP-1) is a calcium-signaling molecule expressed in neurons. Baseline levels of VLP-1 in plasma were somewhat higher in people with mild cognitive impairment who went on to develop Alzheimer’s dementia than in those who did not decline at follow-up (effect size =1.397, p = 0.02). However, the p value was only marginally signficant, and only two studies contributed to the meta-analysis.

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How to interpret a forest plot: Each individual effect size (ES) is a ratio of the mean biomarker level in one condition over the mean level in another condition. An ES equal to 1 means that the two conditions had identical mean values. An ES > 1 indicates higher levels in the first condition, whereas an ES < 1 indicates lower levels in the first condition. The overall ES, indicated by a black diamond, is a weighted average of the individual effect sizes. The weight of each data point was determined by the inverse of the variance and is reflected in the size of each square. The width of the overall ES diamond is determined by the 95 percent confidence interval. Data out of range of the scale, including ES and confidence intervals, are indicated by an arrowhead at the edge of the plot, when applicable. 

Version 3.0, July 2021.