Dementia with Lewy Bodies vs Alzheimer's Disease: sAPPβ (CSF)
sAPPβ is a secreted peptide produced from APP processing along the "amyloidogenic" pathway. Meta-analysis did not show a difference in the levels of sAPPβ in the cerebropsinal fluid of people with dementia with Lewy bodies and people with Alzheimer's disease. However, a paucity of data limited the meta-analysis, with only two eligible studies. For comparison, levels of sAPPβ in cerebrospinal fluid were similar in control subjects and people with Alzheimer's disease.