Cerebral Amyloid Angiopathy vs Alzheimer's Disease: tau-total (CSF)
Meta-analysis did not show a statistically significant difference in the levels of tau in the cerebrospinal fluid of people with cerebral amyloid angiopathy and people with Alzheimer's disease (effect size = 0.686, p = 0.052). However, a paucity of data limited the meta-analysis, with only two eligible studies and a small number of CAA subjects. A meta-analysis that compared people with CAA to control subjects found elevated levels of tau in the paitents (effect size = 1.54, 95% confidence interval: 1.15–2.07, p = 0.004; Charidimou et al., 2018). For comparison, levels of tau in the CSF of AD patients are more than double those in control subjects.