Cerebral Amyloid Angiopathy vs Alzheimer's Disease: Aβ42 (CSF)
Aβ42 was found to be a major component of vascular amyloid deposits (Roher et al., 1993). Meta-analysis did not show a difference in the level of Aβ42 in the cerebrospinal fluid of individuals with cerebral amyloid angiopathy and individuals with Alzheimer’s disease (effect size = 0.862, p = 0.079). However, a paucity of data limited the meta-analysis, with only two eligible studies. A published meta-analysis showed that the level of CSF Aβ42 in individuals with CAA was about half that of controls (Charidimou et al., 2018).