AlzBiomarker

Cerebral Amyloid Angiopathy vs Alzheimer's Disease: Aβ40 (CSF)

Aβ40 is a major component of vascular amyloid deposits (Castaño et al., 1996; Roher et al., 1993). Meta-analysis of two studies showed that Aβ40 levels in the cerebrospinal fluid of people with cerebral amyloid angiopathy were lower than in individuals with Alzheimer’s disease (effect size = 0.753, p <0.0001). A published meta-analysis found that the level of CSF Aβ40 in individuals with CAA was about 70 percent that of controls (Charidimou et al., 2018).

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How to interpret a forest plot: Each individual effect size (ES) is a ratio of the mean biomarker level in one condition over the mean level in another condition. An ES equal to 1 means that the two conditions had identical mean values. An ES > 1 indicates higher levels in the first condition, whereas an ES < 1 indicates lower levels in the first condition. The overall ES, indicated by a black diamond, is a weighted average of the individual effect sizes. The weight of each data point was determined by the inverse of the variance and is reflected in the size of each square. The width of the overall ES diamond is determined by the 95 percent confidence interval. Data out of range of the scale, including ES and confidence intervals, are indicated by an arrowhead at the edge of the plot, when applicable. 

Version 3.0, July 2021.