AlzBiomarker

Alzheimer's Disease vs Control: tau-phospho (CSF)

Meta-analysis Results: A large number of studies over the past 20 years have quantified phosphorylated tau protein in the cerebrospinal fluid of people with Alzheimer’s disease. Meta-analysis of 120 comparisons shows a highly significant increase in the AD group, with overall levels being nearly twofold higher than controls (effect size = 1.882, p < 0.0001). This meta-analysis includes all phospho epitopes of tau; however, the majority of assays used antibodies targeting p181. Levels of phospho-tau in CSF are thought to reflect neurofibrillary tangle pathology in the brain.

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How to interpret a forest plot: Each individual effect size (ES) is a ratio of the mean biomarker level in one condition over the mean level in another condition. An ES equal to 1 means that the two conditions had identical mean values. An ES > 1 indicates higher levels in the first condition, whereas an ES < 1 indicates lower levels in the first condition. The overall ES, indicated by a black diamond, is a weighted average of the individual effect sizes. The weight of each data point was determined by the inverse of the variance and is reflected in the size of each square. The width of the overall ES diamond is determined by the 95 percent confidence interval. Data out of range of the scale, including ES and confidence intervals, are indicated by an arrowhead at the edge of the plot, when applicable. 

Version 2.0, April 2017.

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