Alzbiomarker Cross Disease

This dataset organizes published data on fluid biomarkers for Alzheimer’s disease and other related conditions.  Measurements of biomarker levels from cerebrospinal fluid and blood in non-AD conditions are compared to levels in Alzheimer’s disease, and similar studies are meta-analyzed and visualized in a forest plot. See our Methods page for more details.

Meta-analyses of studies comparing biomarkers in non-AD conditions to controls are beyond the scope of Alzbiomarker.

The heatmap and the table below provide a guide to navigate the meta-analysis results that are available in this dataset.  The colors in the heatmap represent the effect size for each meta-analysis: Blue indicates that the level of the biomarker in the non-AD condition is lower than the level in Alzheimer’s disease, and red indicates an increased level in the non-AD condition compared to Alzheimer’s disease.  Meta-analyses that have a p value less than 0.0001 are indicated with bolded text.  Filter the results by toggling the choices available on the top of the heatmap.

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P Value:
    Aβ Amyloidosis Tauopathies and TDP43opathies Synucleinopathies Prion Diseases Others
  CTRL CAA lvPPA PCA ALS CBS FTD PSP DLB MSA PD PDD FFI gCJD sCJD DEP NPH VaD

APP Metabolites

Aβ38
CSF
1.086           0.784   0.714   0.874           0.557 0.803
Aβ40
CSF
1.098 0.753         0.971 0.768 0.840 0.719 0.889 0.206     0.849 0.911 0.800 0.850
Aβ40
Plasma & Serum
0.952           1.017 1.049     0.962             1.065
Aβ42
CSF
1.818 0.862 0.999 0.926 1.665 1.512 1.657 1.475 1.159 1.547 1.677 1.372     1.119 1.918 1.370 1.308
Aβ42
Plasma & Serum
0.959           1.163 1.160     1.027             1.053
sAPPα
CSF
0.966         0.686 0.862 0.772 0.843 0.707 0.919           0.439  
sAPPα
Plasma & Serum
0.666                                  
sAPPβ
CSF
0.987         0.675 0.712 0.704 0.874 0.735 0.921           0.518  
sAPPβ
Plasma & Serum
1.429                                  

Tau-Related

tau-total
CSF
0.402 0.686 1.039 0.615 0.439 0.494 0.524 0.367 0.492 0.388 0.351 0.430 1.009 7.025 11.684 0.338 0.352 0.595
tau-total
Plasma & Serum
0.728           0.874 0.925     0.574       5.599     0.602
tau-p181
CSF
0.531 0.703 0.959 0.729 0.466 0.513 0.519 0.427 0.560 0.413 0.456 0.527     0.691 0.553 0.352 0.545
tau-p181
Plasma & Serum
0.556         0.365 0.326 0.348     0.612              
tau-p217
CSF
0.091                                  
tau-p217
Plasma & Serum
0.258                                  
tau-p231
CSF
0.170                                  

Synaptic Injury

α-synuclein
CSF
0.845         0.736 0.864 0.693 0.822 0.594 0.758 0.666            
α-synuclein
Plasma & Serum
1.100                                  
neurogranin
CSF
0.622           0.508 0.503 0.580 0.396 0.540 0.574           0.465
neurogranin
Plasma & Serum
1.400                                  

Neuronal Injury

hFABP
CSF
0.696               0.936     0.814            
hFABP
Plasma & Serum
0.949               2.276   1.088              
NFL
CSF
0.505       4.503 1.653 1.848 1.487 1.191 1.801 0.612 0.835   2.002 5.194     1.712
NFL
Plasma & Serum
0.540         1.507 1.167 1.147     0.558              
NSE
CSF
0.683                                 0.709
NSE
Plasma & Serum
1.001                                 0.714
VLP-1
CSF
0.647                                  

Microglial Markers

MCP-1
CSF
0.917         1.035 0.929 0.981   0.960 0.923              
MCP-1
Plasma & Serum
0.962                                  
sTREM2
CSF
0.761           0.923   1.104   0.741              

Astroglial Markers

GFAP
CSF
0.666           1.127               0.774      
GFAP
Plasma & Serum
0.519           0.813                      
YKL-40
CSF
0.733         0.938 1.000 0.948 0.920   0.863     1.304 1.376     0.873
YKL-40
Plasma & Serum
0.411                                  

Blood-Brain Barrier Integrity

albumin ratio
CSF
0.901           1.044   1.260   1.189             1.203
Meta-Analysis Effect Size z score | p value Number of
Comparisons
Number of
Subjects
ALS vs AD: Aβ42 (CSF) Effect Size: 1.665 z score | p value: z = 3.86 | p = 0.00012 Number of Comparisons: 4 Number of Subjects: ALS N=145, AD N=510
ALS vs AD: NFL (CSF) Effect Size: 4.503 z score | p value: z = 15.17 | p <0.0001 Number of Comparisons: 2 Number of Subjects: ALS N=80, AD N=408
ALS vs AD: tau-p181 (CSF) Effect Size: 0.466 z score | p value: z = 10.58 | p <0.0001 Number of Comparisons: 4 Number of Subjects: ALS N=145, AD N=510
ALS vs AD: tau-total (CSF) Effect Size: 0.439 z score | p value: z = 9.21 | p <0.0001 Number of Comparisons: 3 Number of Subjects: ALS N=134, AD N=491
ARD vs AD: tau-total (CSF) Effect Size: 0.463 z score | p value: z = 1.32 | p = 0.18580 Number of Comparisons: 2 Number of Subjects: ARD N=30, AD N=59
CAA vs AD: Aβ40 (CSF) Effect Size: 0.753 z score | p value: z = 4.18 | p <0.0001 Number of Comparisons: 2 Number of Subjects: CAA N=29, AD N=114
CAA vs AD: Aβ42 (CSF) Effect Size: 0.862 z score | p value: z = 1.76 | p = 0.07885 Number of Comparisons: 2 Number of Subjects: CAA N=29, AD N=114
CAA vs AD: tau-p181 (CSF) Effect Size: 0.703 z score | p value: z = 2.32 | p = 0.02060 Number of Comparisons: 2 Number of Subjects: CAA N=29, AD N=114
CAA vs AD: tau-total (CSF) Effect Size: 0.686 z score | p value: z = 1.94 | p = 0.05241 Number of Comparisons: 2 Number of Subjects: CAA N=29, AD N=114
CBS vs AD: Aβ42 (CSF) Effect Size: 1.512 z score | p value: z = 7.05 | p <0.0001 Number of Comparisons: 7 Number of Subjects: CBS N=113, AD N=874
CBS vs AD: MCP-1 (CSF) Effect Size: 1.035 z score | p value: z = 0.35 | p = 0.72423 Number of Comparisons: 2 Number of Subjects: CBS N=29, AD N=76
CBS vs AD: NFL (CSF) Effect Size: 1.653 z score | p value: z = 5.89 | p <0.0001 Number of Comparisons: 7 Number of Subjects: CBS N=104, AD N=689
CBS vs AD: NFL (Plasma and Serum) Effect Size: 1.507 z score | p value: z = 1.34 | p = 0.18010 Number of Comparisons: 2 Number of Subjects: CBS N=83, AD N=89
CBS vs AD: sAPPα (CSF) Effect Size: 0.686 z score | p value: z = 4.13 | p <0.0001 Number of Comparisons: 2 Number of Subjects: CBS N=29, AD N=76
CBS vs AD: sAPPβ (CSF) Effect Size: 0.675 z score | p value: z = 3.33 | p = 0.00088 Number of Comparisons: 3 Number of Subjects: CBS N=50, AD N=148
CBS vs AD: tau-p181 (CSF) Effect Size: 0.513 z score | p value: z = 11.23 | p <0.0001 Number of Comparisons: 10 Number of Subjects: CBS N=156, AD N=933
CBS vs AD: tau-p181 (Plasma and Serum) Effect Size: 0.365 z score | p value: z = 5.4 | p <0.0001 Number of Comparisons: 2 Number of Subjects: CBS N=90, AD N=119
CBS vs AD: tau-total (CSF) Effect Size: 0.494 z score | p value: z = 6.1 | p <0.0001 Number of Comparisons: 11 Number of Subjects: CBS N=174, AD N=1519
CBS vs AD: YKL-40 (CSF) Effect Size: 0.938 z score | p value: z = 0.53 | p = 0.59748 Number of Comparisons: 3 Number of Subjects: CBS N=47, AD N=136
CBS vs AD: α-synuclein (CSF) Effect Size: 0.736 z score | p value: z = 3.41 | p = 0.00065 Number of Comparisons: 2 Number of Subjects: CBS N=26, AD N=74
CTRL vs AD: albumin ratio (CSF) Effect Size: 0.901 z score | p value: z = 3 | p = 0.00272 Number of Comparisons: 21 Number of Subjects: CTRL N=897, AD N=1861
CTRL vs AD: Aβ38 (CSF) Effect Size: 1.086 z score | p value: z = 2.12 | p = 0.03363 Number of Comparisons: 17 Number of Subjects: CTRL N=827, AD N=887
CTRL vs AD: Aβ40 (CSF) Effect Size: 1.098 z score | p value: z = 4.11 | p <0.0001 Number of Comparisons: 50 Number of Subjects: CTRL N=1921, AD N=2422
CTRL vs AD: Aβ40 (Plasma and Serum) Effect Size: 0.952 z score | p value: z = 1.62 | p = 0.10471 Number of Comparisons: 46 Number of Subjects: CTRL N=5311, AD N=3760
CTRL vs AD: Aβ42 (CSF) Effect Size: 1.818 z score | p value: z = 34.3 | p <0.0001 Number of Comparisons: 202 Number of Subjects: CTRL N=10272, AD N=13930
CTRL vs AD: Aβ42 (Plasma and Serum) Effect Size: 0.959 z score | p value: z = 1.9 | p = 0.05783 Number of Comparisons: 51 Number of Subjects: CTRL N=5848, AD N=4151
CTRL vs AD: GFAP (CSF) Effect Size: 0.666 z score | p value: z = 1.92 | p = 0.05530 Number of Comparisons: 5 Number of Subjects: CTRL N=128, AD N=140
CTRL vs AD: GFAP (Plasma and Serum) Effect Size: 0.519 z score | p value: z = 12.24 | p <0.0001 Number of Comparisons: 7 Number of Subjects: CTRL N=1123, AD N=738
CTRL vs AD: hFABP (CSF) Effect Size: 0.696 z score | p value: z = 6.89 | p <0.0001 Number of Comparisons: 7 Number of Subjects: CTRL N=374, AD N=361
CTRL vs AD: hFABP (Plasma and Serum) Effect Size: 0.949 z score | p value: z = 0.86 | p = 0.38915 Number of Comparisons: 3 Number of Subjects: CTRL N=139, AD N=134
CTRL vs AD: MCP-1 (CSF) Effect Size: 0.917 z score | p value: z = 3.12 | p = 0.00181 Number of Comparisons: 11 Number of Subjects: CTRL N=723, AD N=460
CTRL vs AD: MCP-1 (Plasma and Serum) Effect Size: 0.962 z score | p value: z = 0.82 | p = 0.41128 Number of Comparisons: 8 Number of Subjects: CTRL N=723, AD N=1112
CTRL vs AD: neurogranin (CSF) Effect Size: 0.622 z score | p value: z = 7.9 | p <0.0001 Number of Comparisons: 22 Number of Subjects: CTRL N=1389, AD N=1595
CTRL vs AD: neurogranin (Plasma and Serum) Effect Size: 1.400 z score | p value: z = 1.14 | p = 0.25272 Number of Comparisons: 2 Number of Subjects: CTRL N=49, AD N=45
CTRL vs AD: NFL (CSF) Effect Size: 0.505 z score | p value: z = 14.2 | p <0.0001 Number of Comparisons: 29 Number of Subjects: CTRL N=1932, AD N=1672
CTRL vs AD: NFL (Plasma and Serum) Effect Size: 0.540 z score | p value: z = 11.33 | p <0.0001 Number of Comparisons: 15 Number of Subjects: CTRL N=1526, AD N=1053
CTRL vs AD: NSE (CSF) Effect Size: 0.683 z score | p value: z = 2.87 | p = 0.00416 Number of Comparisons: 9 Number of Subjects: CTRL N=211, AD N=293
CTRL vs AD: NSE (Plasma and Serum) Effect Size: 1.001 z score | p value: z = 0.01 | p = 0.99192 Number of Comparisons: 3 Number of Subjects: CTRL N=97, AD N=102
CTRL vs AD: sAPPα (CSF) Effect Size: 0.966 z score | p value: z = 0.78 | p = 0.43779 Number of Comparisons: 14 Number of Subjects: CTRL N=559, AD N=806
CTRL vs AD: sAPPα (Plasma and Serum) Effect Size: 0.666 z score | p value: z = 1.58 | p = 0.11352 Number of Comparisons: 2 Number of Subjects: CTRL N=151, AD N=132
CTRL vs AD: sAPPβ (CSF) Effect Size: 0.987 z score | p value: z = 0.48 | p = 0.62907 Number of Comparisons: 17 Number of Subjects: CTRL N=740, AD N=1031
CTRL vs AD: sAPPβ (Plasma and Serum) Effect Size: 1.429 z score | p value: z = 1.04 | p = 0.30006 Number of Comparisons: 3 Number of Subjects: CTRL N=178, AD N=176
CTRL vs AD: sTREM2 (CSF) Effect Size: 0.761 z score | p value: z = 6.37 | p <0.0001 Number of Comparisons: 12 Number of Subjects: CTRL N=686, AD N=714
CTRL vs AD: tau-p181 (CSF) Effect Size: 0.531 z score | p value: z = 29.11 | p <0.0001 Number of Comparisons: 148 Number of Subjects: CTRL N=8460, AD N=10756
CTRL vs AD: tau-p181 (Plasma and Serum) Effect Size: 0.556 z score | p value: z = 7.94 | p <0.0001 Number of Comparisons: 19 Number of Subjects: CTRL N=1744, AD N=1175
CTRL vs AD: tau-p217 (CSF) Effect Size: 0.091 z score | p value: z = 11.17 | p <0.0001 Number of Comparisons: 2 Number of Subjects: CTRL N=249, AD N=164
CTRL vs AD: tau-p217 (Plasma and Serum) Effect Size: 0.258 z score | p value: z = 1.74 | p = 0.08162 Number of Comparisons: 2 Number of Subjects: CTRL N=393, AD N=252
CTRL vs AD: tau-p231 (CSF) Effect Size: 0.170 z score | p value: z = 4.67 | p <0.0001 Number of Comparisons: 5 Number of Subjects: CTRL N=111, AD N=259
CTRL vs AD: tau-total (CSF) Effect Size: 0.402 z score | p value: z = 39.39 | p <0.0001 Number of Comparisons: 227 Number of Subjects: CTRL N=11056, AD N=15441
CTRL vs AD: tau-total (Plasma and Serum) Effect Size: 0.728 z score | p value: z = 5.53 | p <0.0001 Number of Comparisons: 36 Number of Subjects: CTRL N=4061, AD N=2715
CTRL vs AD: VLP-1 (CSF) Effect Size: 0.647 z score | p value: z = 5.23 | p <0.0001 Number of Comparisons: 7 Number of Subjects: CTRL N=385, AD N=353
CTRL vs AD: YKL-40 (CSF) Effect Size: 0.733 z score | p value: z = 7.39 | p <0.0001 Number of Comparisons: 32 Number of Subjects: CTRL N=1844, AD N=1716
CTRL vs AD: YKL-40 (Plasma and Serum) Effect Size: 0.411 z score | p value: z = 2.43 | p = 0.01521 Number of Comparisons: 4 Number of Subjects: CTRL N=487, AD N=342
CTRL vs AD: α-synuclein (CSF) Effect Size: 0.845 z score | p value: z = 3.55 | p = 0.00038 Number of Comparisons: 24 Number of Subjects: CTRL N=1140, AD N=1237
CTRL vs AD: α-synuclein (Plasma and Serum) Effect Size: 1.100 z score | p value: z = 0.98 | p = 0.32567 Number of Comparisons: 3 Number of Subjects: CTRL N=78, AD N=109
DEP vs AD: Aβ40 (CSF) Effect Size: 0.911 z score | p value: z = 1.72 | p = 0.08504 Number of Comparisons: 2 Number of Subjects: DEP N=43, AD N=174
DEP vs AD: Aβ42 (CSF) Effect Size: 1.918 z score | p value: z = 7.01 | p <0.0001 Number of Comparisons: 5 Number of Subjects: DEP N=86, AD N=298
DEP vs AD: tau-p181 (CSF) Effect Size: 0.553 z score | p value: z = 9.13 | p <0.0001 Number of Comparisons: 3 Number of Subjects: DEP N=56, AD N=203
DEP vs AD: tau-total (CSF) Effect Size: 0.338 z score | p value: z = 10.81 | p <0.0001 Number of Comparisons: 9 Number of Subjects: DEP N=164, AD N=678
DLB vs AD: albumin ratio (CSF) Effect Size: 1.260 z score | p value: z = 3.77 | p = 0.00016 Number of Comparisons: 2 Number of Subjects: DLB N=78, AD N=955
DLB vs AD: Aβ38 (CSF) Effect Size: 0.714 z score | p value: z = 1.95 | p = 0.05149 Number of Comparisons: 3 Number of Subjects: DLB N=111, AD N=205
DLB vs AD: Aβ40 (CSF) Effect Size: 0.840 z score | p value: z = 3.82 | p = 0.00013 Number of Comparisons: 10 Number of Subjects: DLB N=305, AD N=826
DLB vs AD: Aβ42 (CSF) Effect Size: 1.159 z score | p value: z = 5.84 | p <0.0001 Number of Comparisons: 42 Number of Subjects: DLB N=1390, AD N=4292
DLB vs AD: hFABP (CSF) Effect Size: 0.936 z score | p value: z = 0.73 | p = 0.46589 Number of Comparisons: 2 Number of Subjects: DLB N=73, AD N=83
DLB vs AD: hFABP (Plasma and Serum) Effect Size: 2.276 z score | p value: z = 3.29 | p = 0.00100 Number of Comparisons: 2 Number of Subjects: DLB N=50, AD N=58
DLB vs AD: neurogranin (CSF) Effect Size: 0.580 z score | p value: z = 3.36 | p = 0.00078 Number of Comparisons: 4 Number of Subjects: DLB N=79, AD N=643
DLB vs AD: NFL (CSF) Effect Size: 1.191 z score | p value: z = 1.16 | p = 0.24704 Number of Comparisons: 4 Number of Subjects: DLB N=155, AD N=637
DLB vs AD: sAPPα (CSF) Effect Size: 0.843 z score | p value: z = 1.57 | p = 0.11563 Number of Comparisons: 2 Number of Subjects: DLB N=40, AD N=169
DLB vs AD: sAPPβ (CSF) Effect Size: 0.874 z score | p value: z = 0.95 | p = 0.34022 Number of Comparisons: 2 Number of Subjects: DLB N=40, AD N=169
DLB vs AD: sTREM2 (CSF) Effect Size: 1.104 z score | p value: z = 0.86 | p = 0.38894 Number of Comparisons: 2 Number of Subjects: DLB N=39, AD N=152
DLB vs AD: tau-p181 (CSF) Effect Size: 0.560 z score | p value: z = 14.94 | p <0.0001 Number of Comparisons: 38 Number of Subjects: DLB N=1189, AD N=4027
DLB vs AD: tau-total (CSF) Effect Size: 0.492 z score | p value: z = 20.25 | p <0.0001 Number of Comparisons: 46 Number of Subjects: DLB N=1373, AD N=4919
DLB vs AD: YKL-40 (CSF) Effect Size: 0.920 z score | p value: z = 2.22 | p = 0.02654 Number of Comparisons: 5 Number of Subjects: DLB N=122, AD N=231
DLB vs AD: α-synuclein (CSF) Effect Size: 0.822 z score | p value: z = 3.27 | p = 0.00109 Number of Comparisons: 17 Number of Subjects: DLB N=524, AD N=887
FFI vs AD: tau-total (CSF) Effect Size: 1.009 z score | p value: z = 0.08 | p = 0.93416 Number of Comparisons: 2 Number of Subjects: FFI N=29, AD N=149
FTD vs AD: albumin ratio (CSF) Effect Size: 1.044 z score | p value: z = 0.52 | p = 0.60314 Number of Comparisons: 8 Number of Subjects: FTD N=199, AD N=1215
FTD vs AD: Aβ38 (CSF) Effect Size: 0.784 z score | p value: z = 3.1 | p = 0.00196 Number of Comparisons: 8 Number of Subjects: FTD N=185, AD N=474
FTD vs AD: Aβ40 (CSF) Effect Size: 0.971 z score | p value: z = 0.78 | p = 0.43772 Number of Comparisons: 14 Number of Subjects: FTD N=400, AD N=1005
FTD vs AD: Aβ40 (Plasma and Serum) Effect Size: 1.017 z score | p value: z = 0.22 | p = 0.82562 Number of Comparisons: 2 Number of Subjects: FTD N=27, AD N=84
FTD vs AD: Aβ42 (CSF) Effect Size: 1.657 z score | p value: z = 19.06 | p <0.0001 Number of Comparisons: 56 Number of Subjects: FTD N=1484, AD N=5429
FTD vs AD: Aβ42 (Plasma and Serum) Effect Size: 1.163 z score | p value: z = 2.82 | p = 0.00474 Number of Comparisons: 2 Number of Subjects: FTD N=27, AD N=84
FTD vs AD: GFAP (CSF) Effect Size: 1.127 z score | p value: z = 0.67 | p = 0.50435 Number of Comparisons: 3 Number of Subjects: FTD N=66, AD N=81
FTD vs AD: GFAP (Plasma and Serum) Effect Size: 0.813 z score | p value: z = 1.54 | p = 0.12369 Number of Comparisons: 4 Number of Subjects: FTD N=237, AD N=217
FTD vs AD: MCP-1 (CSF) Effect Size: 0.929 z score | p value: z = 1.55 | p = 0.12104 Number of Comparisons: 3 Number of Subjects: FTD N=55, AD N=192
FTD vs AD: neurogranin (CSF) Effect Size: 0.508 z score | p value: z = 8.64 | p <0.0001 Number of Comparisons: 7 Number of Subjects: FTD N=180, AD N=1487
FTD vs AD: NFL (CSF) Effect Size: 1.848 z score | p value: z = 8.78 | p <0.0001 Number of Comparisons: 21 Number of Subjects: FTD N=615, AD N=2140
FTD vs AD: NFL (Plasma and Serum) Effect Size: 1.167 z score | p value: z = 1.67 | p = 0.09501 Number of Comparisons: 10 Number of Subjects: FTD N=394, AD N=421
FTD vs AD: sAPPα (CSF) Effect Size: 0.862 z score | p value: z = 1.96 | p = 0.05017 Number of Comparisons: 5 Number of Subjects: FTD N=118, AD N=366
FTD vs AD: sAPPβ (CSF) Effect Size: 0.712 z score | p value: z = 4.98 | p <0.0001 Number of Comparisons: 11 Number of Subjects: FTD N=292, AD N=848
FTD vs AD: sTREM2 (CSF) Effect Size: 0.923 z score | p value: z = 0.46 | p = 0.64787 Number of Comparisons: 2 Number of Subjects: FTD N=36, AD N=129
FTD vs AD: tau-p181 (CSF) Effect Size: 0.519 z score | p value: z = 18.31 | p <0.0001 Number of Comparisons: 50 Number of Subjects: FTD N=1361, AD N=4551
FTD vs AD: tau-p181 (Plasma and Serum) Effect Size: 0.326 z score | p value: z = 3.94 | p <0.0001 Number of Comparisons: 8 Number of Subjects: FTD N=358, AD N=504
FTD vs AD: tau-total (CSF) Effect Size: 0.524 z score | p value: z = 21.23 | p <0.0001 Number of Comparisons: 70 Number of Subjects: FTD N=1738, AD N=6322
FTD vs AD: tau-total (Plasma and Serum) Effect Size: 0.874 z score | p value: z = 2.55 | p = 0.01080 Number of Comparisons: 6 Number of Subjects: FTD N=148, AD N=323
FTD vs AD: YKL-40 (CSF) Effect Size: 1.000 z score | p value: z = 0.01 | p = 0.99243 Number of Comparisons: 19 Number of Subjects: FTD N=495, AD N=1062
FTD vs AD: α-synuclein (CSF) Effect Size: 0.864 z score | p value: z = 0.73 | p = 0.46551 Number of Comparisons: 4 Number of Subjects: FTD N=102, AD N=218
gCJD vs AD: NFL (CSF) Effect Size: 2.002 z score | p value: z = 2.07 | p = 0.03857 Number of Comparisons: 2 Number of Subjects: gCJD N=27, AD N=87
gCJD vs AD: tau-total (CSF) Effect Size: 7.025 z score | p value: z = 4.93 | p <0.0001 Number of Comparisons: 4 Number of Subjects: gCJD N=65, AD N=191
gCJD vs AD: YKL-40 (CSF) Effect Size: 1.304 z score | p value: z = 3.24 | p = 0.00120 Number of Comparisons: 2 Number of Subjects: gCJD N=22, AD N=112
lvPPA vs AD: Aβ42 (CSF) Effect Size: 0.999 z score | p value: z = 0.03 | p = 0.97589 Number of Comparisons: 2 Number of Subjects: lvPPA N=32, AD N=418
lvPPA vs AD: tau-p181 (CSF) Effect Size: 0.959 z score | p value: z = 0.52 | p = 0.60254 Number of Comparisons: 2 Number of Subjects: lvPPA N=32, AD N=418
lvPPA vs AD: tau-total (CSF) Effect Size: 1.039 z score | p value: z = 0.34 | p = 0.73297 Number of Comparisons: 2 Number of Subjects: lvPPA N=32, AD N=418
MSA vs AD: Aβ40 (CSF) Effect Size: 0.719 z score | p value: z = 5.05 | p <0.0001 Number of Comparisons: 2 Number of Subjects: MSA N=49, AD N=62
MSA vs AD: Aβ42 (CSF) Effect Size: 1.547 z score | p value: z = 12.94 | p <0.0001 Number of Comparisons: 8 Number of Subjects: MSA N=209, AD N=846
MSA vs AD: MCP-1 (CSF) Effect Size: 0.960 z score | p value: z = 0.29 | p = 0.77074 Number of Comparisons: 2 Number of Subjects: MSA N=65, AD N=76
MSA vs AD: neurogranin (CSF) Effect Size: 0.396 z score | p value: z = 7.56 | p <0.0001 Number of Comparisons: 2 Number of Subjects: MSA N=55, AD N=224
MSA vs AD: NFL (CSF) Effect Size: 1.801 z score | p value: z = 3.52 | p = 0.00043 Number of Comparisons: 3 Number of Subjects: MSA N=113, AD N=124
MSA vs AD: sAPPα (CSF) Effect Size: 0.707 z score | p value: z = 5.59 | p <0.0001 Number of Comparisons: 2 Number of Subjects: MSA N=65, AD N=76
MSA vs AD: sAPPβ (CSF) Effect Size: 0.735 z score | p value: z = 4.09 | p <0.0001 Number of Comparisons: 2 Number of Subjects: MSA N=65, AD N=76
MSA vs AD: tau-p181 (CSF) Effect Size: 0.413 z score | p value: z = 14.98 | p <0.0001 Number of Comparisons: 7 Number of Subjects: MSA N=220, AD N=346
MSA vs AD: tau-total (CSF) Effect Size: 0.388 z score | p value: z = 11.27 | p <0.0001 Number of Comparisons: 10 Number of Subjects: MSA N=255, AD N=986
MSA vs AD: α-synuclein (CSF) Effect Size: 0.594 z score | p value: z = 10.49 | p <0.0001 Number of Comparisons: 5 Number of Subjects: MSA N=155, AD N=198
NPH vs AD: Aβ38 (CSF) Effect Size: 0.557 z score | p value: z = 10.84 | p <0.0001 Number of Comparisons: 2 Number of Subjects: NPH N=114, AD N=65
NPH vs AD: Aβ40 (CSF) Effect Size: 0.800 z score | p value: z = 1.18 | p = 0.23866 Number of Comparisons: 4 Number of Subjects: NPH N=137, AD N=98
NPH vs AD: Aβ42 (CSF) Effect Size: 1.370 z score | p value: z = 4.62 | p <0.0001 Number of Comparisons: 11 Number of Subjects: NPH N=508, AD N=775
NPH vs AD: sAPPα (CSF) Effect Size: 0.439 z score | p value: z = 8.52 | p <0.0001 Number of Comparisons: 3 Number of Subjects: NPH N=160, AD N=75
NPH vs AD: sAPPβ (CSF) Effect Size: 0.518 z score | p value: z = 12.78 | p <0.0001 Number of Comparisons: 3 Number of Subjects: NPH N=160, AD N=75
NPH vs AD: tau-p181 (CSF) Effect Size: 0.352 z score | p value: z = 11.2 | p <0.0001 Number of Comparisons: 8 Number of Subjects: NPH N=463, AD N=590
NPH vs AD: tau-total (CSF) Effect Size: 0.352 z score | p value: z = 7.67 | p <0.0001 Number of Comparisons: 11 Number of Subjects: NPH N=508, AD N=775
PCA vs AD: Aβ42 (CSF) Effect Size: 0.926 z score | p value: z = 0.47 | p = 0.64182 Number of Comparisons: 2 Number of Subjects: PCA N=34, AD N=43
PCA vs AD: tau-p181 (CSF) Effect Size: 0.729 z score | p value: z = 1.41 | p = 0.15745 Number of Comparisons: 2 Number of Subjects: PCA N=34, AD N=43
PCA vs AD: tau-total (CSF) Effect Size: 0.615 z score | p value: z = 1.25 | p = 0.21302 Number of Comparisons: 2 Number of Subjects: PCA N=34, AD N=43
PD vs AD: albumin ratio (CSF) Effect Size: 1.189 z score | p value: z = 2.86 | p = 0.00421 Number of Comparisons: 3 Number of Subjects: PD N=53, AD N=120
PD vs AD: Aβ38 (CSF) Effect Size: 0.874 z score | p value: z = 1.5 | p = 0.13296 Number of Comparisons: 3 Number of Subjects: PD N=307, AD N=207
PD vs AD: Aβ40 (CSF) Effect Size: 0.889 z score | p value: z = 2.27 | p = 0.02331 Number of Comparisons: 6 Number of Subjects: PD N=404, AD N=402
PD vs AD: Aβ40 (Plasma and Serum) Effect Size: 0.962 z score | p value: z = 0.78 | p = 0.43687 Number of Comparisons: 2 Number of Subjects: PD N=118, AD N=156
PD vs AD: Aβ42 (CSF) Effect Size: 1.677 z score | p value: z = 20.83 | p <0.0001 Number of Comparisons: 25 Number of Subjects: PD N=1233, AD N=1883
PD vs AD: Aβ42 (Plasma and Serum) Effect Size: 1.027 z score | p value: z = 0.28 | p = 0.77608 Number of Comparisons: 2 Number of Subjects: PD N=118, AD N=156
PD vs AD: hFABP (Plasma and Serum) Effect Size: 1.088 z score | p value: z = 0.5 | p = 0.61367 Number of Comparisons: 3 Number of Subjects: PD N=151, AD N=89
PD vs AD: MCP-1 (CSF) Effect Size: 0.923 z score | p value: z = 2.51 | p = 0.01206 Number of Comparisons: 4 Number of Subjects: PD N=190, AD N=260
PD vs AD: neurogranin (CSF) Effect Size: 0.540 z score | p value: z = 29.06 | p <0.0001 Number of Comparisons: 4 Number of Subjects: PD N=260, AD N=664
PD vs AD: NFL (CSF) Effect Size: 0.612 z score | p value: z = 2.93 | p = 0.00336 Number of Comparisons: 5 Number of Subjects: PD N=262, AD N=557
PD vs AD: NFL (Plasma and Serum) Effect Size: 0.558 z score | p value: z = 5.88 | p <0.0001 Number of Comparisons: 3 Number of Subjects: PD N=77, AD N=260
PD vs AD: sAPPα (CSF) Effect Size: 0.919 z score | p value: z = 0.74 | p = 0.45961 Number of Comparisons: 2 Number of Subjects: PD N=101, AD N=76
PD vs AD: sAPPβ (CSF) Effect Size: 0.921 z score | p value: z = 0.81 | p = 0.41546 Number of Comparisons: 2 Number of Subjects: PD N=101, AD N=76
PD vs AD: sTREM2 (CSF) Effect Size: 0.741 z score | p value: z = 1.16 | p = 0.24591 Number of Comparisons: 2 Number of Subjects: PD N=89, AD N=184
PD vs AD: tau-p181 (CSF) Effect Size: 0.456 z score | p value: z = 18.1 | p <0.0001 Number of Comparisons: 23 Number of Subjects: PD N=1033, AD N=1548
PD vs AD: tau-p181 (Plasma and Serum) Effect Size: 0.612 z score | p value: z = 9.73 | p <0.0001 Number of Comparisons: 3 Number of Subjects: PD N=106, AD N=182
PD vs AD: tau-total (CSF) Effect Size: 0.351 z score | p value: z = 21.96 | p <0.0001 Number of Comparisons: 31 Number of Subjects: PD N=1323, AD N=1985
PD vs AD: tau-total (Plasma and Serum) Effect Size: 0.574 z score | p value: z = 5.43 | p <0.0001 Number of Comparisons: 3 Number of Subjects: PD N=130, AD N=185
PD vs AD: YKL-40 (CSF) Effect Size: 0.863 z score | p value: z = 2.63 | p = 0.00857 Number of Comparisons: 2 Number of Subjects: PD N=104, AD N=94
PD vs AD: α-synuclein (CSF) Effect Size: 0.758 z score | p value: z = 4.48 | p <0.0001 Number of Comparisons: 13 Number of Subjects: PD N=661, AD N=538
PDD vs AD: Aβ40 (CSF) Effect Size: 0.206 z score | p value: z = 1.11 | p = 0.26732 Number of Comparisons: 2 Number of Subjects: PDD N=54, AD N=98
PDD vs AD: Aβ42 (CSF) Effect Size: 1.372 z score | p value: z = 5.08 | p <0.0001 Number of Comparisons: 9 Number of Subjects: PDD N=216, AD N=967
PDD vs AD: hFABP (CSF) Effect Size: 0.814 z score | p value: z = 1.68 | p = 0.09326 Number of Comparisons: 2 Number of Subjects: PDD N=45, AD N=83
PDD vs AD: neurogranin (CSF) Effect Size: 0.574 z score | p value: z = 5.83 | p <0.0001 Number of Comparisons: 2 Number of Subjects: PDD N=58, AD N=521
PDD vs AD: NFL (CSF) Effect Size: 0.835 z score | p value: z = 0.74 | p = 0.46161 Number of Comparisons: 2 Number of Subjects: PDD N=62, AD N=445
PDD vs AD: tau-p181 (CSF) Effect Size: 0.527 z score | p value: z = 9.96 | p <0.0001 Number of Comparisons: 6 Number of Subjects: PDD N=135, AD N=574
PDD vs AD: tau-total (CSF) Effect Size: 0.430 z score | p value: z = 18.04 | p <0.0001 Number of Comparisons: 10 Number of Subjects: PDD N=222, AD N=968
PDD vs AD: α-synuclein (CSF) Effect Size: 0.666 z score | p value: z = 7.38 | p <0.0001 Number of Comparisons: 5 Number of Subjects: PDD N=104, AD N=174
PSP vs AD: Aβ40 (CSF) Effect Size: 0.768 z score | p value: z = 4.02 | p <0.0001 Number of Comparisons: 2 Number of Subjects: PSP N=50, AD N=62
PSP vs AD: Aβ40 (Plasma and Serum) Effect Size: 1.049 z score | p value: z = 1.32 | p = 0.18756 Number of Comparisons: 2 Number of Subjects: PSP N=41, AD N=45
PSP vs AD: Aβ42 (CSF) Effect Size: 1.475 z score | p value: z = 8.36 | p <0.0001 Number of Comparisons: 10 Number of Subjects: PSP N=250, AD N=1209
PSP vs AD: Aβ42 (Plasma and Serum) Effect Size: 1.160 z score | p value: z = 2.34 | p = 0.01929 Number of Comparisons: 2 Number of Subjects: PSP N=41, AD N=45
PSP vs AD: MCP-1 (CSF) Effect Size: 0.981 z score | p value: z = 0.35 | p = 0.72448 Number of Comparisons: 2 Number of Subjects: PSP N=67, AD N=76
PSP vs AD: neurogranin (CSF) Effect Size: 0.503 z score | p value: z = 4.2 | p <0.0001 Number of Comparisons: 3 Number of Subjects: PSP N=87, AD N=621
PSP vs AD: NFL (CSF) Effect Size: 1.487 z score | p value: z = 5.95 | p <0.0001 Number of Comparisons: 6 Number of Subjects: PSP N=183, AD N=616
PSP vs AD: NFL (Plasma and Serum) Effect Size: 1.147 z score | p value: z = 0.8 | p = 0.42314 Number of Comparisons: 3 Number of Subjects: PSP N=96, AD N=210
PSP vs AD: sAPPα (CSF) Effect Size: 0.772 z score | p value: z = 3.96 | p <0.0001 Number of Comparisons: 2 Number of Subjects: PSP N=67, AD N=76
PSP vs AD: sAPPβ (CSF) Effect Size: 0.704 z score | p value: z = 2.6 | p = 0.00946 Number of Comparisons: 3 Number of Subjects: PSP N=95, AD N=148
PSP vs AD: tau-p181 (CSF) Effect Size: 0.427 z score | p value: z = 14.08 | p <0.0001 Number of Comparisons: 12 Number of Subjects: PSP N=290, AD N=1148
PSP vs AD: tau-p181 (Plasma and Serum) Effect Size: 0.348 z score | p value: z = 4.11 | p <0.0001 Number of Comparisons: 3 Number of Subjects: PSP N=99, AD N=240
PSP vs AD: tau-total (CSF) Effect Size: 0.367 z score | p value: z = 18.4 | p <0.0001 Number of Comparisons: 15 Number of Subjects: PSP N=337, AD N=1932
PSP vs AD: tau-total (Plasma and Serum) Effect Size: 0.925 z score | p value: z = 0.5 | p = 0.61611 Number of Comparisons: 2 Number of Subjects: PSP N=56, AD N=164
PSP vs AD: YKL-40 (CSF) Effect Size: 0.948 z score | p value: z = 0.63 | p = 0.52850 Number of Comparisons: 3 Number of Subjects: PSP N=77, AD N=136
PSP vs AD: α-synuclein (CSF) Effect Size: 0.693 z score | p value: z = 7.57 | p <0.0001 Number of Comparisons: 4 Number of Subjects: PSP N=109, AD N=99
sCJD vs AD: Aβ40 (CSF) Effect Size: 0.849 z score | p value: z = 0.98 | p = 0.32886 Number of Comparisons: 2 Number of Subjects: sCJD N=611, AD N=158
sCJD vs AD: Aβ42 (CSF) Effect Size: 1.119 z score | p value: z = 1.58 | p = 0.11492 Number of Comparisons: 4 Number of Subjects: sCJD N=1283, AD N=521
sCJD vs AD: GFAP (CSF) Effect Size: 0.774 z score | p value: z = 0.54 | p = 0.58878 Number of Comparisons: 2 Number of Subjects: sCJD N=107, AD N=58
sCJD vs AD: NFL (CSF) Effect Size: 5.194 z score | p value: z = 12.45 | p <0.0001 Number of Comparisons: 7 Number of Subjects: sCJD N=468, AD N=354
sCJD vs AD: tau-p181 (CSF) Effect Size: 0.691 z score | p value: z = 7.48 | p <0.0001 Number of Comparisons: 3 Number of Subjects: sCJD N=676, AD N=448
sCJD vs AD: tau-total (CSF) Effect Size: 11.684 z score | p value: z = 19.88 | p <0.0001 Number of Comparisons: 11 Number of Subjects: sCJD N=1633, AD N=1006
sCJD vs AD: tau-total (Plasma and Serum) Effect Size: 5.599 z score | p value: z = 2.03 | p = 0.04242 Number of Comparisons: 2 Number of Subjects: sCJD N=148, AD N=65
sCJD vs AD: YKL-40 (CSF) Effect Size: 1.376 z score | p value: z = 4.09 | p <0.0001 Number of Comparisons: 3 Number of Subjects: sCJD N=202, AD N=152
VaD vs AD: albumin ratio (CSF) Effect Size: 1.203 z score | p value: z = 1.83 | p = 0.06719 Number of Comparisons: 9 Number of Subjects: VaD N=429, AD N=1243
VaD vs AD: Aβ38 (CSF) Effect Size: 0.803 z score | p value: z = 5.13 | p <0.0001 Number of Comparisons: 2 Number of Subjects: VaD N=109, AD N=125
VaD vs AD: Aβ40 (CSF) Effect Size: 0.850 z score | p value: z = 2.93 | p = 0.00339 Number of Comparisons: 4 Number of Subjects: VaD N=148, AD N=206
VaD vs AD: Aβ40 (Plasma and Serum) Effect Size: 1.065 z score | p value: z = 1.11 | p = 0.26662 Number of Comparisons: 3 Number of Subjects: VaD N=102, AD N=224
VaD vs AD: Aβ42 (CSF) Effect Size: 1.308 z score | p value: z = 8.56 | p <0.0001 Number of Comparisons: 26 Number of Subjects: VaD N=601, AD N=2819
VaD vs AD: Aβ42 (Plasma and Serum) Effect Size: 1.053 z score | p value: z = 0.56 | p = 0.57514 Number of Comparisons: 4 Number of Subjects: VaD N=121, AD N=266
VaD vs AD: neurogranin (CSF) Effect Size: 0.465 z score | p value: z = 8.93 | p <0.0001 Number of Comparisons: 2 Number of Subjects: VaD N=54, AD N=96
VaD vs AD: NFL (CSF) Effect Size: 1.712 z score | p value: z = 2.87 | p = 0.00404 Number of Comparisons: 5 Number of Subjects: VaD N=158, AD N=265
VaD vs AD: NSE (CSF) Effect Size: 0.709 z score | p value: z = 3.16 | p = 0.00157 Number of Comparisons: 4 Number of Subjects: VaD N=78, AD N=115
VaD vs AD: NSE (Plasma and Serum) Effect Size: 0.714 z score | p value: z = 2.61 | p = 0.00903 Number of Comparisons: 2 Number of Subjects: VaD N=24, AD N=48
VaD vs AD: tau-p181 (CSF) Effect Size: 0.545 z score | p value: z = 10.51 | p <0.0001 Number of Comparisons: 19 Number of Subjects: VaD N=442, AD N=2166
VaD vs AD: tau-total (CSF) Effect Size: 0.595 z score | p value: z = 8.12 | p <0.0001 Number of Comparisons: 37 Number of Subjects: VaD N=899, AD N=3943
VaD vs AD: tau-total (Plasma and Serum) Effect Size: 0.602 z score | p value: z = 2.04 | p = 0.04156 Number of Comparisons: 4 Number of Subjects: VaD N=97, AD N=215
VaD vs AD: YKL-40 (CSF) Effect Size: 0.873 z score | p value: z = 2.62 | p = 0.00882 Number of Comparisons: 3 Number of Subjects: VaD N=72, AD N=178

Further Reading

News

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Webinars

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  3. Untapped Resource? New Study to Boost Acceptance of CSF Analysis
  4. Together at Last, Top Five Biomarkers Model Stages of AD