In the plaque-ridden mouse brain, microglia that had taken up Aβ activated a unique gene-expression profile. It faded after microglia were moved to plaque-free environs.
Scientists know that both genetic and environmental risk factors contribute to sporadic Parkinson’s disease, and that one suspected environmental culprit is manganese...
At a conference in Heidelberg, researchers proposed that Aβ oligomers trigger local translation of tau in cytosol and dendrites, and that targeting this aberrant tau may preserve synapses.
Unlike iPSC-derived neurons, those created directly from fibroblasts reflect the donor's age and disease status. Epigenetic modifications appear to make the difference.
While the FDA weighs aducanumab’s marketing license application, Alzheimer’s researchers agree that the agency’s own statistician correctly assessed the data as weak. Most prefer that one more trial be done.
A “mammalian-wide interspersed repeat-natural antisense transcript” blocks translation of tau mRNA. Other MIR-NATS may act on α-synuclein and APP.
Activating the G protein-coupled receptor PAC1R in the mouse brain prompts the proteasome to clear tangles.
A large multinational epidemiology study finds only small and inconsistent associations.
When pulsed through the skull, ultrasound restored synaptic signaling, neurogenesis, and memory, in old mice.
Downregulation of a chemokine receptor traps T cells in the meninges. Glymph drainage slows, amyloid burden rises.
Treatments that promote neurogenesis and elevate BDNF act as exercise does to improve memory in mouse models of Alzheimer’s disease.
Take a three-dimensional tour of the plaques and tangles of mouse and human brains as they develop Alzheimer’s disease-related pathology.
The co-chaperone DnaJC5 teams up with Hsc70 to guide potentially toxic proteins out of neurons. Whether this facilitates transcellular propagation remains to be seen.
Microglia may transport tau between neurons by taking it up and secreting it in exosomal packages. Blocking exosome synthesis stopped the transfer.
As scientists celebrate the 2012 Nobel Prize in Physiology or Medicine, researchers are looking to traditional and modern stem cell sources to treat diseases of the brain...