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Michael J. Fox Foundation Launches Big PD Biomarker Study

A $40 million multicenter biomarker study for Parkinson disease progression is off and running, with enrollment underway at 10 of 18 sites in the U.S. and Europe. In design and operation, the  Parkinson's Progression Markers Initiative  (PPMI) ...

Guidelines Bring Needed Change, Though Not Enough for Some

U.S. guidelines for assessing Alzheimer's disease (AD) neuropathology are getting a much-needed facelift. The existing ones, in place since 1997, had fallen out of step with the current understanding of AD as a disease with a long preclinical stage. ...

Update on DIAN, API, A4: All About Biomarkers, Trials, and Funds

Alzforum readers who follow the science of preclinical Alzheimer's and prevention may have heard about three independent but complementary programs that together are laying the groundwork for secondary prevention trials across the spectrum of rare to ...

Deep-Brain Stimulation: Surgical Relief for Parkinson's and Beyond

In this series, ARF takes stock of deep-brain stimulation after more than a decade of life-altering procedures,  In deep brain stimulation, surgeons implant wires into the brain and hook them up to a pacemaker-like stimulator implanted in the chest, which ...

Cortical Hubs to Rich Clubs—Linking Brain Connectivity to Function

If you find it hard to keep up with Facebook, LinkedIn, and other social networks, spare a thought for the brain. With 100 to 500 trillion synaptic connections, the human brain dwarfs all of them. How do those connections work to formulate thought, recall ...

ALS Ice Bucket Challenge Returns for a Repeat Performance in 2015

Last year's ice bucket challenge for amyotrophic lateral sclerosis netted $220 million in donations for ALS charities, and the 2015 challenge is off to a strong start with $100,000 from Major League Baseball. Alzforum looks at how all that money is ...

Modern Microscopy

Modern Microscopy Skims Surface of Living Minds and Spines Modern Microscopy Plumbs the Depths of Brain Tissue ...

Task Force Focuses on Tracing Brain Amyloid

Online training for use of Amyvid, the first FDA-approved Aβ imaging ligand, is now up and running,even as a task force convened by the Society of Nuclear Medicine and the Alzheimer's Association scrambles to formulate some expert guidelines on how ...

To Sleep, Perchance to Clean…the Brain, Make Memories

Researchers have tied sleep to clearance of waste products such as excess Aβ. New research suggests this clearance may be driven by a change in the extracellular ion composition, which swells the interstitial fluid. Other work finds an essential role for ...

Metabolomics Comes of Age

Move over, genome, transcriptome, proteome. The latest ome aims to map every metabolite linked to human health and disease. Metabolomics, although still a nascent field, offers hope for biomarkers and treatments in neurodegenerative disease. The field& ...

Medical Foods for Alzheimer's: Palatable Therapy or Snake Oil?

In the absence of truly effective treatments, and in the presence of a rapidly growing, dementia-prone population of elders, it's perhaps no surprise that people are increasingly open to products claiming even the slightest hint of promise, however ...

Alzheimer's Association International Conference 2013

Cerebrospinal Fluid Tau Climbs in Aβ Mouse Models Coverage Denial For Amyloid Scans Riles Alzheimer’s Community Pooled GWAS Reveals New Alzheimer’s Genes and Pathways Are Subtle Memory Concerns a Sign of Future Dementia? Clinical Trials Roundup: Four Hits ...

International Conference on Alzheimer's Disease 2006

Madrid: ICAD Conference Draws to a Close Madrid: BACE Found to Have Big Job in Wrapping Motoneurons Madrid: Why Do People Drop Out of Trials? Madrid: Stressed Brain—SNP Carriers Can Have Cake and Eat It Madrid: BACE News Roundup, Part 1 Madrid: BACE News ...

International Conference on Alzheimer's Disease 2004

Philadelphia: All Eyes on PIB Imaging—Is It Coming Along? Philadelphia: All Is Not Well with the Statin Story Philadelphia: Can a Shrinking Brain Be Good for You? Philadelphia: Dementia Types Just Won’t Fit into Little Boxes Philadelphia: Diagnosis Light ...

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