Two papers advance the drive to develop an Alzheimer's vaccine, one looking at the antibody response in some of the Elan trial participants, the other using sophisticated methods to analyze the epitope recognized by antibodies generated in response to Aβ42 immunization.
Thomas Wisniewski, Einar Sigurdsson, and colleagues at New York University report that they have prevented amyloid-β deposition by immunizing a mouse model of Alzheimer's disease with a nontoxic Aβ homologue...
Almost exactly 100 years after Alois Alzheimer saw his first patient who complained about "having lost herself," <strong>Christian Haass</strong> and <strong>Roger Nitsch</strong> invited a panel of international opinion leaders to gather in the German Black Forest...
In this month’s Brain, researchers at the Universities of Milan and Genoa, Italy, report that immunizing C57/Bl6 mice with Aβ42 generated an inflammatory response similar to an autoimmune disease in the brains of these mice...
Early last month, 118 scientists braved a snowstorm on the Eastern seaboard to gather at Cold Spring Harbor Laboratory on Long Island, New York, for a conference on therapeutic opportunities in neurodegenerative diseases...
Crumbling microtubules, those slender filaments that aid a variety of cellular processes from cell division to vesicle trafficking, could lead to motor neuron disease...
After well-deserved "thank you’s" to Yves Christen and Jacqueline Mervaillie of the IPSEN Foundation, who organized this conference held on 17 March 2003, Brad Hyman’s introductory remarks reviewed...
Collaborative research directed by Floyd E. Bloom of Neurome Inc. and the Scripps Research Institute shows that dramatic changes occur in the brains of mice expressing mutant human forms of AβPP long before any Aβ has been deposited...
Keith Crutcher reports on the World Alzheimer Congress in Stockholm. "From the relatively crude days of CT scans to the truly impressive detail now being offered by functional MRI, this revolution in imaging technology is making it possible to study the course of AD in ways previously unimaginable...."
Stockholm. Read our coverage of the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm, starting with this report of advances in imaging methods and a promising new live amyloid marker.
Magnetic resonance imaging (MRI) of the brain shows great promise as a diagnostic tool. Neurodegenerative and psychiatric disorders can lead to changes in the brain that this imaging technique can pick up...
Joseph F. Poduslo and colleagues at Mayo Clinic report in the August issue of Nature Biotechnology (pp. 868-872) on a technique for imaging Aβ deposits in living brain...
In the December 2 online Journal of Biological Chemistry, researchers extend to mice earlier in-vitro observations linking Aβ degradation to the activity of endothelin converting enzyme (ECE)...