Alzheimer’s Research Restarts, Cautiously
As the SARS-Cov-2 infection peak passes in some areas, scientists are resuming lab work and clinical studies, albeit with new safety protocols in place. Regions differ greatly in how fast they can reopen.
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TMEM106B Variants Regulate Gene Modules, TDP-43 Pathology
A GWAS of co-expression modules identifies a haplotype that disrupts lysosomes and myelination. ApoE4 and Aβ regulate the same module.
Neuronal SRPX2 Spoils Microglial Appetite for Synapses
This neuronal protein regulates the complement cascade in the developing brain. Could it do the same in aging or neurodegenerative disease?
Klotho VS Variant Preserves Memory by Preventing Tangles
Carriers accumulate fewer tangles than noncarriers for a given amount of amyloid, explaining how the gene variant may lower a person’s Alzheimer’s risk.
Tunneling Nanotubes—How Pericytes Control Blood Flow
In the mouse retina, these tender threads connect pericytes on nearby capillaries. They enable cells to coordinate constriction and dilation of blood vessels in response to neuronal activity.
Can Loss of a Single Protein Domain Cause ‘Alzheimer’s’ in Mice?
Without the WD domain of Atg16L1, required for a newly discovered type of endocytosis, old mice develop hallmark pathologies of AD.
With Tau in Synapses, NO Neurovascular Coupling
Dendritic tau suppresses production of nitric oxide, which prevents blood vessels from dilating in response to neural activity.
Herpes Simplex Virus Triggers Amyloidosis in 3D Neural Cultures
Grown on doughnut-shaped supports, the cultures survive for years. They offer a versatile system for studying Alzheimer’s disease, the authors claim.
Paper Alert: Those PIGs! Spatial Transcriptomics Add Human Data
In the Alzheimer’s brain, too, plaques trigger a coordinated inflammatory response from microglia and astrocytes. A preprint paper had shown the same for mice.
Rogue APP Claim Embroiled in Contamination Concerns
A 2018 report that had spotted extra copies of APP lurking in neuronal genomes has come under scrutiny, with claims that the result is due to contamination. Does a response from the original authors bolster their claim?
Nixing TMEM106b Fans the Flames of Progranulin Deficiency
Three studies agree that TMEM106b/progranulin double knockouts develop more extreme lysosomal dysfunction, inflammation, and motor deficits than PGRN KOs.
Excitotoxicity: Could a New Class of Drug Stop a Bad TRP?
TRP cation channels combine with extrasynaptic NMDA glutamate receptors to set off mitochondrial meltdown and cell death. Blocking the interaction stops excitotoxicity.
Alzheimer's Risk Genes Nip at Hippocampus Throughout Life
ApoE4 does so much more strongly than the other known genes collected in a polygenic risk score.
In the United States, Racial Disparities in Dementia Risk Persist
Despite overall falling dementia rates in the U.S., black people remain more susceptible than whites.
Simulating Tangle Spread Along Axons, Scientists Predict Tau PET Patterns
The modeling approach reinforces the idea that tau pathology propagates through the brain’s physical architecture, including neuronal networks.
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