They are no match made in heaven, but in neurons, the two proteins responsible for amyloid plaques and neurofibrillary tangles might...
A lively platter of slide talks on APP processing and β-secretase (BACE) activities yielded a few interesting tidbits on the...
In this week’s Nature, researchers report the first successful crystal structure of a bacterial presenilin homologue...
Amyloid plaques and tau tangles sprout in human neuron cultures grown in a supportive gel. Researchers think this system may closely model human disease and aid in drug discovery.
Mice expressing presenilin harboring AD-associated mutations resemble mice lacking the enzyme altogether, suggesting that the mutations fully inactivate the enzyme.
Levels of CSF biomarker neurogranin correlate with imaging measures of synaptic integrity in ADNI cohort.
Eli Lilly has given up on regulatory submission for mild AD, but leaves door open to seeking approval for earlier disease stages if three ongoing studies succeed.
Patients on solanezumab saw small improvements on multiple secondary endpoints.
Danish study correlates higher natural levels of lithium to lower incidence of Alzheimer’s disease
CryoEM reveals high-resolution view of full length of Aβ42 in a novel conformation.
Researchers claim that young cases of cerebral amyloid angiopathy may have been caused by contaminated surgical equipment.
Researchers from Spain describe changes in cannabinoid receptors in the brains of AD patients, as well as...
The transcriptomes of single immune cells in the mouse brain identify specific disease-associated microglia (DAM), which eat away at Aβ deposits.
The material, previously used to treat children with growth deficiencies, triggered amyloid deposition in transgenic mice.
First look at substrate interactions reveals similarities but some surprises.
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