A New Explanation for Dendritic Tau: It’s Made There
At a conference in Heidelberg, researchers proposed that Aβ oligomers trigger local translation of tau in cytosol and dendrites, and that targeting this aberrant tau may preserve synapses.
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Alzheimer’s Proteomics Treasure Trove?
Analysis of brain tissue from Alzheimer’s patients offers a glimpse of proteomic changes in the disease.
Large Majority of Football Players in BU Brain Bank Have CTE
The prevalence of chronic traumatic encephalopathy supports a link between multiple concussions and this degenerative tauopathy, though the sample is self-selected.
sAPP Binds GABA Receptor, and More News on APP
An astrocytic Aβ protease, destabilization of γ-secretase by FAD mutations, and an sAPP receptor all made their debuts at Heidelberg conference.
Finally, a Blood Test for Alzheimer’s?
At AAIC, researchers debuted a method that detects changes in plasma Aβ42 in people with brain amyloid. If confirmed, a widely available screening test for presymptomatic AD could follow.
Alzheimer's Association International Conference 2017
Finally, a Blood Test for Alzheimer’s? In Clinical Use, Amyloid Scans Change Two-Thirds of Treatment Plans Searching for New AD Risk Variants? Move Beyond GWAS Monomeric Seeds and Oligomeric Clouds—Proteopathy News from AAIC Planning the First Primary Pre
Necroptosis Rampant in the Alzheimer’s Brain?
Markers of necroptosis peppered postmortem brain tissue from people with AD. Gene expression implicates RIP kinases. Could shuttering this cell death pathway save neurons?
Do APP and Parkinson’s Proteins Collude to Cause Neurodegeneration?
One report implicates APP’s intracellular domain in neuron loss due to LRRK2; another accuses the AICD fragment of regulating mitochondrial dynamics via Pink-1.
Monomeric Seeds and Oligomeric Clouds—Proteopathy News from AAIC
In London, researchers claimed that a monomer is the minimal structure required for tau strains. On the other hand, the sky seems the limit for the number of Aβ strains that form in an individual brain.
Phosphorylation of FUS Does Away with Droplets
FUS proteins tend to link up and form liquid droplets and, from those, aggregates. Phosphorylation of the protein’s low-complexity domain repels these associations.
The Search for the Missing AD Heritability Turns Up New Rare Variants
High-throughput sequencing yields surprises. Learn about pathogenic variants in endosomal genes, an algorithm to nab the worst SORL1 mutations, dominant PS1 mutations arising de novo, and tau duplications.
All Signs Point to Tau Tangles as the Culprit in Fading Memory
Researchers at AAIC reinforced the idea that tau pathology drives cognitive decline, although amyloid plaques were implicated in semantic memory deficits.
CSF and Brain Markers Highlight Different Facets of Dementia
Researchers at AAIC described different correlates of CSF and PET measures of Aβ and tau.
Shot of Klotho Boosts Memory In Aging and Diseased Mice
Injecting a piece of this anti-aging protein days before memory testing improved performance in mice young and old, as well as those that overexpress α-synuclein.
New Ties between AD and the Stages, Waves, and Molecules of Sleep
At AAIC 2017, scientists offered new clues on sleep and AD neuropathology. They identified parts of the brain that may be involved and highlighted the benefits of treating sleep disorders.
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