Microglia Give Astrocytes License to Kill
Three cytokines released by activated immune cells in the brain turn astrocytes into neuron-killing machines.
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Antisense Oligos Tango with Tau Transcripts to Reverse Tauopathy
Disabling human tau mRNA in mice prevents—even reverses—tau buildup, suggesting a potential treatment for a multitude of human tauopathies.
Led Astray: Pathology Tied to “Grid Cell” Malfunction in Tauopathy Model
A new mouse study correlates neurofibrillary tangles with navigation difficulties and impaired firing of “grid cells” in the entorhinal cortex.
Consensus Reached: Dieting Monkeys Survive Longer
Two parallel studies found different answers as to whether calorie-restricted macaques live longer than ones that eat their fill. A joint analysis sets the record straight.
Solanezumab: Did Aβ ‘Reflux’ From Blood Confound Target Engagement in CSF?
Convened by ARUK to learn from the antibody’s billion-dollar bust, industry and academic leaders declare insufficient CNS target engagement, say peripheral sink did not work, and brainstorm how to move forward.
ARUK Roundtable: Where Now for Alzheimer's Disease Research?
Solanezumab: Did Aβ ‘Reflux’ From Blood Confound Target Engagement in CSF? After Solanezumab: Where Should Alzheimer’s Research Go? At an expert meeting convened by Alzheimer’s Research UK, scientists from Eli Lilly shared Aβ biomarker data from the Exped
Delirium Makes its Own Mark on Cognitive Decline
The acute state of confusion not only accelerates memory loss on its own, but also worsens decline caused by other pathologies, including Alzheimer’s disease.
At the Heart of Every ALS RNA Aggregate, a Single Transcript
In induced cells from people with a C9ORF72 expansion, the number of mutant transcripts matched the number of RNA foci per cell.
Barfing Up Balls of Trouble Keeps Some Neurons Healthy
Neurons of the humble roundworm pack damaged organelles and protein aggregates into giant vesicles and heave them out into extracellular space. Do our neurons do that, too?
Microbes in the Gut Egg on Aβ Pathology in Mice
Transgenic mouse models devoid of gut microbes make fewer Aβ plaques.
Case Closed: Testosterone Does Not Boost Cognition
A well-controlled trials shows that a year of treatment offers no cognitive benefit for older men with low testosterone levels.
Bizarre Twist on Amyloid Structure
Produced by the dreaded MRSA bacterium, PSMα3 is the first known example of a natural peptide that forms amyloid fibers made not of β-sheets, but of neatly stacked α-helices.
Pee P75: A Potential Biomarker of ALS Progression?
ALS patients eliminate more p75 neurotrophin receptor than do healthy controls. P75 urine levels rise as disease worsens.
Consortium to Seek Biomarkers for Vascular Cognitive Impairment
NIH funds a five-year project to validate biomarkers for clinical trials.
Clinical-Grade Stem Cells Fail to Replicate Benefit of Research Lines
Quality control issues may have scuppered clinical trials.
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