Parkinson's Therapies Seek to Stem Progression
Trialists are shooting new arrows at the disease, including compounds that tweak autophagy, neuroinflammation, and glycolipid recycling.
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Beware That Toast: Gluten Sensitivity in Some People with ALS?
In a preliminary study, 15 percent of people with ALS had antibodies against an enzyme that processes the wheat protein gluten.
Alzheimer's Disease Research Summit 2015: Expanding the Horizon
At an NIH conference in Washington, D.C., experts from beyond Alzheimer’s research discussed ways to beef up data collection and patient participation.
Herpesvirus: Trigger for Many Brain Pathologies?
At Quebec conference, researchers considered multiple aspects of herpesvirus biology that may come in to play in AD.
The Air We Breathe—How Might Pollution Hurt the Brain?
Chemicals and particulates may slip across the blood-brain barrier or travel up olfactory nerves to directly affect brain cells. What are the consequences for cognition?
Air Pollution and Dementia—Through Hazy Data, Links Emerge
Growing evidence suggests exposure to air pollution increases risk of brain damage and dementia. More definitive research is needed.
Can Induced Neurons Identify Early Signs of Neurodegeneration?
In patient-derived neurons, tau mutations scupper lysosomes and SORLA shunts APP through different types of endosomes.
Shiny SEQUIN: New Technique Counts Synapses Over Large Brain Volumes
Using a form of confocal microscopy and automated software, the method allows researchers to rapidly identify functional synapses within brain structures.
FDA Approves Edaravone for Treatment of ALS
The drug slows functional decline in patients with mild disease and should be available to U.S. patients in August.
After a Summer of Icy Showers, What Will Happen with Buckets of Cash for ALS?
The ALS Ice Bucket Challenge has yielded more than $100 million—what research projects should get a share of the action?
Diagnosis and Prognosis in the “Other” Motor Neuron Diseases
Amyotrophic lateral sclerosis, already a rare condition affecting one to three people in 100,000, nonetheless garners most of the attention in the field of motor neuron disease...
Disadvantaged Neighborhoods Raise Odds of Alzheimer’s
People who lived in impoverished neighborhoods in their last year of life had greater odds of having died with AD neuropathology.
Does Common Structure Explain Cross-Seeding of Fibrils?
Islet amyloid protein and Aβ fibrils share similar folds.
Meet the New Progressive Tauopathy: CTE in Athletes, Soldiers
Prompted by striking brain pathology in both contact sport athletes and military veterans, scientists are now defining a new disease...
Primary Tauopathies Get New PET Ligands
Autopsy data confirm that current tau PET tracers are unsuitable for some primary tauopathies. CryoEM structures help researchers find new ligands for tau and α-synuclein.
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