Can Researchers Detect Dementia With Lewy Bodies at the Prodromal Stage?
The field is searching for a combination of clinical features and biomarkers that will identify the disease in people with mild cognitive impairment.
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Consortia Assemble Worldwide to Take on Lewy Body Dementia
The field is rapidly building the infrastructure for biomarker studies and large clinical trials.
Don’t Be an Enrollment Loser: Throw Your Own Swab-a-Palooza!
Recruitment, recruitment, recruitment: Registries get creative in how they promote research engagement and fill prevention trials.
Physical Activity May Shield the Brain from the Onslaught of Aβ
Middle-aged people who exercise more are less likely to become amyloid-positive. In late life, people with brain amyloid who exercise declined more slowly and had less brain shrinkage over the following years.
Ribosomal Protein Spurs Faulty Translation of Nucleotide Repeats
RPS25 helps translate repetitive snippets of RNA that are associated with neurodegenerative diseases. Knocking it down reduces protein aggregates and cell death.
High and Low Hemoglobin Levels Tied to Alzheimer’s
Too much or too little serum hemoglobin increases risk for Alzheimer’s and other dementias by 20 percent or more.
ASOs: Wave of the Future in Alzheimer’s Therapeutics?
As the Alzheimer’s field suffers smackdowns in trials of small molecules and antibodies, antisense oligonucleotides are quietly coming along—and looking safe so far.
DIAD: Families from Argentina, Canada, Minnesota Rally a Global Community
A brother’s survival guilt, a journalist tracing her mutation to Lebanon, a student freezing her eggs ahead of a primary prevention trial—DIAN family members are stirring their growing community to act against Alzheimer’s disease.
International Conference on Alzheimer's and Parkinson's Diseases 2019
At AD/PD Conference, New Alzheimer’s Genes Reinforce Known Pathways Expression, Expression, Expression—Time to Get on Board with eQTLs APP Upp: Mutation Nixes Six Amino Acids from Aβ, Spurs Aggregation Parsing How Alzheimer’s Genetic Risk Works Through ...
Genetics Propels DIAN Toward Therapies
Nearly 30 years after the first Alzheimer’s gene discoveries, genetics once again drives recruitment, scientific progress, and therapy development in the Dominantly Inherited Alzheimer’s Network.
Expression, Expression, Expression—Time to Get on Board with eQTLs
A tool of modern genetics, expression studies link GWAS hits to specific cell types, providing clues to pathogenesis. Microglia come up again and again.
Crenezumab Update: Baseline Data from Colombian Prevention Trial
At AAIC, researchers presented baseline data from an ongoing, five-year study asking whether the anti-Aβ antibody crenezumab can forestall cognitive decline in autosomal-dominant Alzheimer’s disease.
2019 DIAD Family Conference: Mutation, Participation, Innovation.
DIAD: Families from Argentina, Canada, Minnesota Rally a Global Community Genetics Propels DIAN Toward Therapies ASOs: Wave of the Future in Alzheimer’s Therapeutics? As DIAN Wraps Up Anti-Aβ Drug Arms, it Sprouts Tau, Primary Prevention Arms On July 13, ...
Paper Alert: MS4A Variants May Sway Alzheimer’s Risk Via TREM2
Different polymorphisms in MS4A genes up- or downregulate levels of TREM2, modulating levels of the shed ectodomain in the cerebrospinal fluid and AD risk.
Triple Threat: Tau, Atrophy, and Arteriolosclerosis Push CTE Toward Dementia
Among former National Football League players who died with CTE, tau tangles, crumbling white matter, and arteriolosclerosis independently contributed to dementia.
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