Green Glowing Prions Gather in Golgi
Normal cellular prion protein (PrPc) is easy to spot on the surface of neurons and glia in the CNS by antibody staining. But when the protein converts...
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New Neuronal Fare—A Dish of Stem Cells with a Side of Jumping Genes
This week, light from two very different angles was shone on the process of neurodevelopment. Writing in PNAS, researchers described a method to...
You Gotta Keep 'em Separated—New Strategy for Targeting γ-secretase?
The intramembrane protease activity of γ-secretase is a prime target for therapeutic strategies aimed at treating Alzheimer disease by...
Dublin: The Tao of Tau
Followers of the Tao eastern philosophy advocate complete simplicity and naturalness; followers of the tau protein...
Sorrento: Sorting Out Shedding of Ectodomains
Not only the sweet scent from the ubiquitous citrus trees aroused the senses at the 7th international AD/PD meeting in Sorrento, but the unlikely theme of...
San Diego: ApoE Effects Explored
Studies on ApoE have exploded since it was discovered that those carrying one copy of ApoE4 allele are more likely to get the disease than...
γ-Secretase Activity is Mostly Intracellular—Needs PEN-2 C-terminus
A troika of papers provides evidence that γ-secretase is primarily localized intracellularly and needs the C-terminus of PEN-2 for complete integration...
CRISPR Suppresses BACE1 and Plaques in Mice
Deleting BACE1 with CRISPR nanocomplexes tempered Aβ pathology and boosted memory.
The Lactic Acid Shuttle—It May Change How We Image the Brain
In today’s Science, researchers at Cornell University provide compelling evidence that neurons preferentially use lactate as a source of energy...
St. Moritz: Part 3. This Research Isn't Folding Up: Genetics, Transport, Seeding, Protein Microscopy
This story is a continuation of the St. Moritz series started on Monday, 24 May 2004...
SUMO versus Ubiquitin: A Fight for Huntington’s Disease?
Ubiquitin may be everywhere, but when it comes to polyglutamine diseases like Huntington’s (HD), SUMO-1 (small ubiquitin-like modifier 1) may have just as much clout...
Dying to Bind: DENN/MADD Promotes Neuron Death in AD Brain
Researchers who follow the ups and downs of protein expression in Alzheimer’s disease (AD) may well think they are being taken on a roller coaster ride. Early on, many proteins are...
Running the ApoE Marathon…
The Science Fiction channel occasionally runs a marathon of "Twilight Zone:" Back-to-back episodes all day long, each one related to the other through novel scripts with interesting ideas that border on fantasy...
Another Huntingtin Partner Points Toward Proteasome
Polyglutamine (poly Q) expansion in the huntingtin protein (htt) causes Huntington's disease (HD), yet it remains unclear clear how this expansion induces the cellular and neurological damage of the disease...
Stockholm: Educated Guessing Game: Which Genes Does “Other” APP Snippet Regulate?
Researchers in several labs are trying to discover the genes whose expression might be controlled by the C-terminal fragment of APP. The answer is not yet in, but read about some clues presented at the 8th International Conference on Alzheimer’s Disease and Related Disorders...
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