γ-Secretase Activity is Mostly Intracellular—Needs PEN-2 C-terminus
A troika of papers provides evidence that γ-secretase is primarily localized intracellularly and needs the C-terminus of PEN-2 for complete integration...
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CRISPR Suppresses BACE1 and Plaques in Mice
Deleting BACE1 with CRISPR nanocomplexes tempered Aβ pathology and boosted memory.
The Lactic Acid Shuttle—It May Change How We Image the Brain
In today’s Science, researchers at Cornell University provide compelling evidence that neurons preferentially use lactate as a source of energy...
St. Moritz: Part 3. This Research Isn't Folding Up: Genetics, Transport, Seeding, Protein Microscopy
This story is a continuation of the St. Moritz series started on Monday, 24 May 2004...
SUMO versus Ubiquitin: A Fight for Huntington’s Disease?
Ubiquitin may be everywhere, but when it comes to polyglutamine diseases like Huntington’s (HD), SUMO-1 (small ubiquitin-like modifier 1) may have just as much clout...
Dying to Bind: DENN/MADD Promotes Neuron Death in AD Brain
Researchers who follow the ups and downs of protein expression in Alzheimer’s disease (AD) may well think they are being taken on a roller coaster ride. Early on, many proteins are...
Running the ApoE Marathon…
The Science Fiction channel occasionally runs a marathon of "Twilight Zone:" Back-to-back episodes all day long, each one related to the other through novel scripts with interesting ideas that border on fantasy...
Another Huntingtin Partner Points Toward Proteasome
Polyglutamine (poly Q) expansion in the huntingtin protein (htt) causes Huntington's disease (HD), yet it remains unclear clear how this expansion induces the cellular and neurological damage of the disease...
Stockholm: Educated Guessing Game: Which Genes Does “Other” APP Snippet Regulate?
Researchers in several labs are trying to discover the genes whose expression might be controlled by the C-terminal fragment of APP. The answer is not yet in, but read about some clues presented at the 8th International Conference on Alzheimer’s Disease and Related Disorders...
New Role for NO in Neuronal Apoptosis
In today’s Science, researchers from the Burnham Institute, La Jolla, California, report a new pathway that can cause neuronal apoptosis, or programmed cell death—the covalent modification of extracellular matrix metalloproteinases (MMPs)....
Orlando: Adding to ADDLs: Where Are They; What Might They Be Doing?
As the amyloid pathology is shifting away from blaming predominantly amyloid plaques to now pointing a second accusing finger to smaller, non-deposited aggregates of the Aβ peptide...
The Biology of α-Synuclein and Lewy Body Disease Workshop Meeting
The Biology of α-Synuclein and Lewy body Disease Workshop Meeting Cosponsored by NIA and NINDS, Bethesda, Maryland, July 16-17, 2001...
Aβ and Tau Accumulation in an Animal Model of Brain Trauma
Douglas Smith and his colleagues at the University of Pennsylvania may have filled a gap in research on long-term, neurodegeneration sequelae of brain injuries...
American Society for Cell Biology 38th Annual Meeting: More About Tau
Maas et al. (Abstract 2285) studied how phosphorylation of two different regions in tau proteins affects binding of tau protein to the plasma-membrane (PM). The two major phosphorylation sites studied...
American Society for Cell Biology 38th Annual Meeting, San Francisco, 12-16 December, 1998
A special interest subgroup meeting on 'Tau protein in Neurodegenerative Diseases' was organized by Gloria Lee, University of Iowa. This was a timely and stimulating meeting...
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