Invasion of the Microtubules: Mutant Tau Deforms Neuronal Nuclei
In neurons derived from FTD patients, microtubules distort the nucleus, warping its normally rounded membrane and disrupting communication with the cytoplasm.
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Neurofilament in Blood Foretells Early Onset Alzheimer’s
In familial Alzheimer’s disease, rise in NfL in the blood precedes disease onset by 16 years.
Dementia: Frailty Hastens It, Physical Activity Wards It Off
Frail people may be more likely to have Aβ plaques and neurofibrillary tangles; when they do, they are more likely to have dementia. Physical activity correlated with better global cognition, regardless of brain pathology.
SPRINT MIND Data Published, Follow-Up Extended
Reducing systolic blood pressure staves off cognitive decline, but what about dementia?
Do Brain Changes at Menopause Make Women More Prone to Alzheimer’s?
At AAIC, scientists said that alterations in how the aging female brain uses energy and metabolizes fat may leave APOE4 carriers particularly susceptible to tau pathology.
Studies Point to DNA Difficulties in ALS/FTD
New work implicates changes in chromatin structure and failed DNA repair in neurodegeneration.
New C9ORF72 Mice Develop Symptoms Resembling ALS/FTD
Compared with previously published model lines, these animals develop more features of amyotrophic lateral sclerosis and frontotemporal dementia.
C9ORF72 Mice A-OK Despite Toxic RNAs, Peptides
Mouse lines made by two different labs replicate the molecular pathology, but not the neurodegeneration, of ALS and FTD based on C9ORF72 expansions.
Unexpected Polypeptides Pop Up in Huntington’s Disease
In a process known as repeat-associated non-ATG translation, neurons and glia make alanine, serine, cysteine, and leucine chains from the huntingtin gene.
Listen Up, Gene Silencing Strikes a Chord at RNA Meeting
Scientists say treatments to muzzle faulty genes are making some headway.
RNA Regulator Locked Out of Nucleus by C9ORF72 Repeats
The RNA-binding protein hnRNP A3 can help rid a cell of the repeat RNAs, but the RNAs interfere with its nuclear localization.
Researchers Revel in C9ORF72 Advances at RNA Symposium
The latest news on C9ORF72 includes a genetic modifier, various animal models, and a potential treatment to untangle stable, guanine-based structures formed by expanded repeats.
Sense, Antisense: C9ORF72 Makes Both Forms of RNA, Peptides
A repeat expansion that causes neurodegenerative disease is transcribed both forward and backward, producing sense and antisense RNAs and multiple polypeptides.
Transfecting Motor Neurons Made Easy: Try Magnets
Researchers have described a protocol using magnetic beads...
Midlife Peripheral Inflammation May Drive Later Cognitive Decline
A longitudinal study finds that middle-aged people with the highest levels of inflammation markers in their blood succumb to the greatest cognitive decline over the next 20 years.
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