First Round of Awards from Chan Zuckerberg Initiative Announced
The awards total $52 million, divided among 17 early career investigators and nine collaborative science teams.
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International Conference on Frontotemporal Dementia 2018
11th ICFTD Meeting in Sydney Sorts Out Clinical Subtypes Natural History Studies Provide Foundation for FTD Research Tracking Onset and Progression of Frontotemporal Dementia A Proteomics Dive into Cause of Frontotemporal Dementia Encompassing more than ...
Pig Model of ALS Mimics Human Disease
Swine that express mutated human SOD1 exhibit the hallmarks of ALS pathology, including aggregates and degeneration in motor neurons, preceded by a lengthy preclinical phase.
How Immune Cells From Blood Beget Aging in Brain
At SfN, some scientists described how circulating immune cells deliver aging to the mouse hippocampus; others held off parkinsonism by blocking the effects of eotaxin’s rise in blood. Human trials are starting.
How Does The NIA-AA Framework Measure Up Against Real Data?
Researchers are applying the proposed 2018 NIA-AA diagnostic criteria to three large, standing cohorts. How did the research framework perform?
World Dementia Council Takes Stock of Progress, Challenges
Five years after its creation, the WDC met in London to reflect, articulate next steps, and announce more sharing of BACE trial data.
Toxic Tau: Who Are You, and Where Are You From?
Recent conferences revealed that tau is most toxic in oligomeric form, that tau oligomers propagate throughout the brain, and that tau oligomers might harm synapses from within or via astrocytes.
Society for Neuroscience Annual Meeting 2018
Toxic Stew of Aβ Dimers Hides Out in Human Plaques How Immune Cells From Blood Beget Aging in Brain Toxic Tau: Who Are You, and Where Are You From? Tau Silences, Aβ Inflames; Hitting Excitatory Synapses Hardest When Glial Clocks Fall Out of Sync, ...
When Glial Clocks Fall Out of Sync, Inflammation Ensues
Disrupting circadian clocks in astrocytes and microglia unleashed harmful responses in these glial cells, leading to neuronal damage.
Stem Cell Model Nails Link Between Tauopathy and GABAergic Dysfunction
By marrying iPSCs, human genomic data, and analysis of postmortem tissue, researchers tied loss of GABAergic signaling to tauopathies such as FTD and PSP, but not AD.
Could a Blood Test for Tau Diagnose Alzheimer’s Disease?
An ultrasensitive assay picked up elevated concentrations of N-terminal tau fragments in the blood of people with AD.
Does Epigenetic Modification by Aβ Offer New Take on Therapy?
Recent failures of clinical trials targeting amyloid-β in mild to moderate Alzheimer’s disease (AD) have led to claims that the interventions are too little too late...
Without TREM2, Plaques Grow Fast in Mice, Have Less ApoE
Absent the receptor, microglia ignore Aβ seeds and new plaques, which then absorb little ApoE and stay diffuse.
Imaging Inflammation: Can Glial PET Tracers Make a Mark?
The burgeoning proliferation in glia during neuroinflammation could indicate disease course and the efficacy of potential medicines...
Deadline to Weigh In on New Biomarker Guidance Approaches
Stakeholders have until February 11 to comment on draft FDA guidance for biomarker qualification.
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