TDP-43 Routes Mapped in Alzheimer’s, Frontotemporal Dementia
Misfolded TDP-43 spreads along defined pathways in Alzheimer’s and frontotemporal dementia, tracing axonal routes between neurons.
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National Institutes of Health Tackles Irreproducibility Problem
The National Institutes of Health is testing pilot initiatives to address the problem of irreproducible scientific results.
Blocking Cell Death Molecule Calms Gaucher’s Disease in Mice
Taking down a cellular henchman linked to a cell death pathway relieves symptoms of a lysosomal storage disorder in mice. Researchers hope the pathway could lead to a treatment.
Less Is More: High-Affinity Antibodies Block Blood-Brain Barrier Conduit
Using the transferrin receptor to deliver therapeutics to the brain is tricky—antibodies that bind too tightly stall in blood vessel cells and shut down transport.
Acid Bath Turns Cells Pluripotent
Scientists claim to turn differentiated mouse cells into pluripotent ones with a brief dip in an acid bath—no genetic tweaks necessary.
Exome–Network Combination Uncovers New Disease Genes
Combining exome sequencing with gene interaction analysis allowed researchers to identify 18 new genes for an inherited movement disorder. This method could lead to genes linked to other neurodegenerative diseases.
Brave New World? Technology in Dementia Diagnosis, Care
Do you associate technology with youth? Picture this woman doing an automated telephone assessment and think again. Modern gadgets stand poised to transform dementia research and care. Researchers are harnessing the power of computers, digital cameras, an
LRRK2 Interactions Identify New Parkinson’s Genes, Implicate Autophagy
Proteins that interact with the Parkinson’s risk gene LRRK2 point to protein trafficking and degradation as causes of pathogenesis.
Escort Service: A Cytoplasmic Role for TDP-43
Once considered a nuclear homebody, TDP-43 ventures out to accompany mRNAs down axons to nerve terminals where the transcripts can be turned into protein.
Aggressive Hypertension Treatment Accelerates Brain Atrophy in Diabetics
Aggressively treating high blood pressure and cholesterol in older adults with diabetes does not prevent cognitive decline, and results in more brain shrinkage.
Grants to Explore Boundaries Between Alzheimer’s and Parkinson’s
A new grant opportunity will fund projects aimed at understanding the similarities and differences between biomarkers of Alzheimer’s and Parkinson’s diseases.
Alpha-Synuclein Types Congregate in Presynapse—Which Is the Bad One?
Live imaging of the mouse brain offers a rare view of α-synuclein dynamics at presynaptic terminals, and raises questions about which form of the protein triggers synaptic dysfunction.
Death in a Dish: Astrocytes from ALS Patients Flick Necroptosis Switch in Motor Neurons
In a cell culture system, astrocytes from people with ALS kill motor neurons. The model could yield more discoveries about the fundamental biology of this disease.
SORLA Serves Up Aβ for Destruction
It’s not just for tugging APP around the neuron: The SORLA receptor may also bind Aβ and hasten its demise.
What’s the FUS About? New ALS Mouse Model Thickens the Plot
Mutant FUS meddles with RNA splicing and DNA damage repair in transgenic mice that succumb to disease.
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