Toward FTD Therapeutic Trials: Diagnosis Firm, Outcomes Still Soft
Scientists from academia, industry, and funding organizations met to discuss precompetitive steps in the preparation for clinical trials for frontotemporal degeneration...
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Scientists from academia, industry, and funding organizations met to discuss precompetitive steps in the preparation for clinical trials for frontotemporal degeneration...
In an organ as highly vascular as the brain, optimal performance depends on keeping the plumbing shipshape...
Having one parent with Alzheimer disease is hard enough; having two must be devastating...
TDP-43 clogs neurons in some cases of amyotrophic lateral sclerosis, frontotemporal dementia, and Alzheimer disease...
One purpose of the FTSG meeting was to give its scientists an opportunity to show the Food and Drug Administration how far their research has come...
It’s not all about amyloid and tau...
Dealing with trash poses a constant challenge not only for municipalities but also for neurons, where specialized organelles called lysosomes take on the task...
Lysosome malfunction caused by an organelle's inability to clear lipids or other waste from the cell plays a central role in lysosomal storage diseases...
Like the caretaker of a condemned building shutting off the lights for the last time, DNA methyltransferases shut off motor neuron genes during apoptosis...
Peer pressure often evokes unexpected behavior, and protein partners might do the same...
TDP-43, linked to both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, could be joining the ranks of amyloid proteins...
The secretase BACE1 kicks off the process of snipping Aβ from amyloid precursor protein (APP), but what else does this protease do?...
ALS is a disease of lower motor neurons and upper motor neurons (UMNs), but whether UMN degeneration in mouse models closely mirrors human pathology has been unclear...
If there is one thing motor neurons cannot handle, it seems to be perturbations to their RNA machinery...
TDP-43 and FUS: so alike...
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